TY - JOUR AU - Grace, Dr. V. M. Berlin PY - 2016/06/29 Y2 - 2024/03/28 TI - Anti-lymphoma Activity of Averrhoa bilimbi Fruit Extract in Swiss Albino Mice JF - Asian Journal of Pharmaceutics (AJP) JA - AJP VL - 10 IS - 2 SE - ORIGINAL ARTICLES DO - 10.22377/ajp.v10i2.643 UR - https://asiapharmaceutics.info/index.php/ajp/article/view/643 SP - AB - <p>Aim: To evaluate the effect of Averrhoa bilimbi fruit extract against Dalton’s ascitic lymphoma (DAL) induced<br />in Swiss albino mice. Materials and Methods: DAL cell line was injected via intraperitoneal to Swiss albino<br />mice and was treated with A. bilimbi fruit extract for 15 days. Then, the animals were sacrificed on 15th day to<br />test hematological parameters, body weight, and tumor volume. The in vitro growth inhibition effect of A. bilimbi<br />fruit extract on DAL cell line was also studied using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide<br />(MTT) assay. Results and Discussion: The A. bilimbi fruit extract showed promising anti-lymphoma activity in<br />Swiss albino mice. Treatment of A. bilimbi normalized the hematological parameters significantly (**P &lt; 0.01) by<br />decreasing the high level of white blood cell and by increasing the levels of red blood cells and hemoglobin count<br />when compared with DAL control mice. The treated mice group with A. bilimbi fruit extract resulted in significant<br />(P &lt; 0.01) decrease in body weight when compared with the control. The MTT assay also has shown a significant<br />growth inhibition percent (97.96%) for the fruit extract treatment. Conclusion: The current study revealed the<br />anti-lymphoma activity of the A. bilimbi fruit extract against DAL cell line induced Swiss albino mice.</p> ER -