Standarization and optimization of micromeretic properties of nimesulide for processing into a tablet dosage form by crystalo-co-agglomeration technology

Subhra Prakash Bhattacharyya, Indrani Bhattacharyya, Niranjan Patro

Abstract


The present study was undertaken to prepare direct compressible tablets of nimesulide by altering its physical properties with the help of the method crystallo-co-agglomeration technology. Nimesulide is a widely used nonsteroidal anti- inflammatory drugs type of drug and is very useful in the treatment of arthritis. Because of its poor flowability character, tablets of nimesulide cannot be prepared by direct compression. An attempt has been taken to improve the tableting property by altering the micromeretic properties, like flow rate, Carr index, Hausner ratio and angle of repose. Conformation of improvement of compressibility and other processing problems was studied by Heckel analysis and Kawakita constant using a hydraulic press under a pressure of 0.5, 1, 2 and 4 tonnes for 10 s. The tablets were prepared by direct compression of
nimesulide agglomerates using two different types of polymers, polyethelene glycol (PEG6000) and ethyl cellulose (EC) in different ratios (50, 100 and 200 mg).The drug release shows different patterns for the various percentages of PEG and EC.


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References


Singla AK, Chawla M, Singh A. Nimesulide: Some pharmaceutical and

pharmacological aspects and update. J Pharm Pharmacol 2000;52:

-86.

Lipsky PE. The clinical potential of cyclooxygenase-2-specific inhibitors.

Am J Med 1999;106:51-7.

Kawashima Y, Takeuchi H, Niwa T, Hino T, Kihara K. Development of

a emulsion-solvent-diffusion preparation method of agglomerated

crystals for direct tableting and evaluation of their compressibility’s.

J Soc Powder Technol 1989;26:659-65.

Kawashima Y, Aoki S, Takenama H, Miyake Y. Preparation of spherically

agglomerated crystals of aminophylline. J Pharm Sci 1984;73:1407-9.

Pawar AP, Paradkar AR, Kadam SS, Mahadik KR. Crystallo-co-

agglomeration: A Novel Technique to Obtain Ibuprofen-Paracetamol

Agglomerates. AAPS PharmSciTech 2004;5:e44.

Kawashima Y, Okumara M, Takenaka H. The effect of temperature on

the Spherical crystallization of salicylic acid. Powder Technol 1984;39:

Paradkar AR, Pawar AP, Chordiya JK, Patil VB, Ketkar AR. Spherical

crystallization of celecoxib. Drug Develop Ind Pharm 2002;28:1213-20.

Sun CC. A material sparing method for simultaneous determination

of true density and powder compaction properties: Aspartame as an

example. Int J Pharm 2006;326:94-9.

Gonnissen Y, Remon JP, Vervaet C. Development of directly compressible

powders via co-spray drying. Eur J Pharm Biopharm 2007;67:220-6.

Zhang Y, Law Y, Chakrabarti S. Physical properties and compact analysis

of commonly used direct compression binders. AAPS PharmSciTech

;4:e62.

Wells JI, Swarbrick J, Boylan JC. Encyclopedia of pharmaceutical

technology. Vol-14, New York: Marcel Dekker; 1997. p. 401-18.




DOI: http://dx.doi.org/10.22377/ajp.v4i1.118

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