Formulation and evaluation of naproxen sodium orodispersible tablets – A sublimation technique

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Published: Aug 27, 2014
DOI: https://doi.org/10.22377/ajp.v4i1.124

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S Jeevanandham
D Dhachinamoorthi
K B Chandra Sekhar
M Muthukumaran
N Sriram
J Joysaruby

Abstract

The rationale of this investigation was to develop fast dissolving tablets of naproxen sodium using camphor as a subliming agent. Orodispersible tablets of naproxen sodium were prepared by the wet granulation technique using camphor as a subliming agent and sodium starch glycolate together with crosscarmellose sodium as superdisintegrants. Camphor was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed into tablets. Alternatively, tablets were first prepared and later exposed to vacuum.The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, and in vitro dissolution. All the formulations showed low weight variation with dispersion time less than 55 s and rapid in vitro dissolution. Sublimation of camphor from tablets resulted in superior
tablets as compared with the tablets prepared from granules that were exposed to vacuum. The results revealed that the tablets containing the subliming agent had a good dissolution profile.The drug content of all the formulations was within the
acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved naproxen sodium dissolution could be prepared by sublimation of tablets containing a suitable subliming agent. This work helped
in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile.

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How to Cite
Jeevanandham, S., Dhachinamoorthi, D., Sekhar, K. B. C., Muthukumaran, M., Sriram, N., & Joysaruby, J. (2014). Formulation and evaluation of naproxen sodium orodispersible tablets – A sublimation technique. Asian Journal of Pharmaceutics (AJP), 4(1). https://doi.org/10.22377/ajp.v4i1.124
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Vol. 4 No. 1 (2010): Jan-Mar
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References

Chang R, Guo X, Burnside B, Couch R. A review of fast dissolving tablets. Pharm Tech North Am 2000;12:52-8.

Bi Y, Sunada H, Yonezawa Y, Danjo K, Iida K. Preparation and evaluation

of compressed tablets rapidly disintegrating in the oral cavity. Chem

Pharm Bull (Tokyo) 1996;44:2121-7.

Mishra DN, Bindal M, Singh SK, Kumar SG. Spray dried excipient base:

a novel technique for the formulation of orally disintegrating tablets.

Chem Pharm Bull 2006;54:99-102.

Fu Y, Jeong SH, Park K. Fast-melting tablets based on highly plastic

granules. J Control Release 2005;109:203-10.

Sammour OA, Hammad MA, Megrab NA, Zidan AS. Formulation and

optimization of mouth dissolve tablets containing rofecoxib solid

dispersion. AAPS PharmSciTech 2006;7:E55.

Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation

design and optimization of mouth dissolve tablets of nimesulide using

vacuum drying technique. AAPS PharmSciTech 2004;5:e36.

Suresh S, Pandit V, Joshi HP. Preparation and evaluation of mouth

dissolving tablets of salbutamol sulphate. Indian J Pharm Sci

;69:467-9.

Heinemann H, Rothe W. Preparation of porous tablets. US patent 3

026. May 20, 1975.

Knistch A, Hagen E, Munz HD. Production of porous tablets. US patent

134 843. January 16, 1979.

Roser BJ, Blair J. Rapidly soluble oral dosage forms, methods of making the same and composition thereof. US patent 5 762 961, June 9,

Ahmed IS, Fatahalla FA. Pilot study of relative bioavailability of two

oral formulations of ketoprofen in healthy subjects, a fast dissolving

lyophilized tablet as compared to immediate release tablet. Drug

Develop Ind Pharm 2007;33:505-11.

Ahmed IS, Nafadi MM, Fatahalla FA. Formulation of fast dissolving

ketoprofen tablet using freeze drying in blister technique. Drug

Develop Ind Pharm 2006;32:437-42.

Corveleyn S, Remon JP. Formulation and production of rapidly

disintegrating tablets by lyophilization using hydrochlorothiazide as

a model drug. Int J Pharm 1997;152:215-25.

Remon JP, Corveleyn S. Freeze-dried rapidly disintegrating tablets. US

patent 6 010 719, January 4, 2000.

Marshall K, Lachman N, Liberman HA. The theory and practice of industrial pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1987. p. 66-9.

Kimura S, Imai T, Otagiri M, Pharmaceutical evaluation of Ibuprofen syrup containing low molecular weight gelatin. J Pharm Sci 1992;81:141-4.

Yunxia B, Yorinobu Y, Kazumi D, Akinobu O. Preparation and evaluation

of oral tablet rapidly dissolving in oral cavity. Chem Pharm Bull

;44:2121-7.