Effect of method of preparation on pioglitazone HCl-β-cyclodextrin inclusion complexes

Shrikant P Beloshe, Dhanyakumar D Chougule, Rohit R Shah, Dhananjay S Ghodke, Nagnath D Pawar, Rahul P Ghaste

Abstract


Pioglitazone HCl is an antidiabetic agent with poor aqueous solubility. Inclusion complexes of pioglitazone HCl were prepared with β-cyclodextrin using various methods (physical mixing, kneading method, co-precipitation). The main
aim of the present invention is to study the effect of the method of preparation on the dissolution profiles of pioglitazone HCl-β-Cyclodextrin inclusion complexes. The phase solubility profile of pioglitazone HCl with β-cyclodextrin was classified
as AL-type and stability constant with 1:1 molar ratio was 115.45, calculated from the phase solubility diagram. Formation of the inclusion complex between pioglitazone HCl and β-cyclodextrin was confirmed by the Fourier Transform Infrared (FT- IR) spectroscopy. The dissolution profile of inclusion complexes were determined and compared with those of pioglitazone HCl alone and its physical mixtures.The dissolution rate of the pioglitazone HCl-β-cyclodextrin inclusion complex prepared by the co-precipitation method was six times higher when compared with the pure drug. The method of complexation of
pioglitazone HCl in β-CD increased the dissolution rate of the drug in the following order: Coppt > KM > PM >Drug.


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DOI: http://dx.doi.org/10.22377/ajp.v4i2.142

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