Associations of Insertion-deletion Polymorphism of Angiotensin-converting Enzyme with the Risk of Preeclampsia Development among Pregnant Women in Central Russia
Main Article Content
Abstract
Objectives: The associations of the insertion-deletion angiotensin-converting enzyme (I/D ACE) genetic polymorphism with the risk of preeclampsia development were studied. Materials and Methods: The study group included 350 women: 100 women with a physiological pregnancy and 250 pregnant women with preeclampsia. All women underwent the typing of I/D polymorphism of the ACE gene. Results: The pregnant women with the preeclampsia of the 2nd degree of severity showed the lowest concentration of genotype II ACE (11.00%) as compared with pregnant women without preeclampsia (25.00%; odds ratio [OR] = 0.37; P = 0.017; Pcor = 0.051). With the preeclampsia of the 3rd degree of severity, the minimum frequency of the genotype II ACE (7.27%) and the maximum frequency of the allele D ACE (62.73%) are recorded among pregnant women as compared with the pregnant women without preeclampsia (25.00%; OR = 0.24; P = 0.01; Pcor = 0.03 and 49.50%, OR = 1.72, P = 0.03, respectively). Conclusions: Thus, the D ACE allele is associated with the risk of preeclampsia development of the 3rd degree of severity, and the ACE genotype II is a protective factor of preeclampsia development of the 2nd and the 3rd degree of severity.
Downloads
Article Details
How to Cite
Reshetnikov, E. A. (2017). Associations of Insertion-deletion Polymorphism of Angiotensin-converting Enzyme with the Risk of Preeclampsia Development among Pregnant Women in Central Russia. Asian Journal of Pharmaceutics (AJP), 11(03). https://doi.org/10.22377/ajp.v11i03.1471
Section
ORIGINAL ARTICLES
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.