Orodispersible tablets: An overview

Suresh Bandari, Rajendar Kumar Mittapalli, Ramesh Gannu

Abstract


Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules.This review describes the various formulation aspects, disintegrants employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations,
and drugs explored in this field.


Full Text:

PDF

References


Lindgren S, Janzon L. Dysphagia: Prevalence of swallowing complaints

and clinical finding. Med Clin North Am 1993;77:3-5.

Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral

drug delivery: A review. Pharm Sci Technol Today 2000;3:138-45.

Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating

tablets: Developments, technologies, taste-masking and clinical studies.

Crit Rev Ther Drug Carrier Sys 2004;21:433-76.

Seager H. Drug-delivery products and the Zydis fast-dissolving dosage

form. J Pharm Pharmacol 1998;50:375-82.

Habib W, Khankari RK, Hontz J. Fast-dissolve drug delivery systems.

Crit Rev Ther Drug Carrier Sys 2000;17:61-72.

Dobetti L. Fast disintegrating tablets. US Patent 2003;6:596,311.

Brown D. Orally disintegrating tablets-taste over speed. Drug Del Tech

;3:58-61.

Behnke K, Sogaard J, Martin S, Bauml J, Ravindran AV, Agren H, et al.

Mirtazapine orally disintegrating tablet versus sertraline: A prospective

onset of action study. J Clin Psychopharmacol 2003;23:358-64.

Jaccard TT, Leyder J. Une nouvelle forme galenique le lyoc. Ann Pharm

Fr 1985;43:123-31.

Dollo G, Chevanne F, Le Corre P, Chemtob C, Le Verge R. Bioavailability

of phloroglucinol in man. J Pharm Belg 1999;54:75-82.

Gafitanu E, Dumistracel I, Antochi S. Formulations and bioavailability

of propyphenazone in lyophilized tablets. Rev Med Chir Soc Med Nat

Iasi 1991;95:127-8.

Clarke A, Brewer F, Johnson ES, Mallard N, Hartig F, Taylor S, et al. A

new formulation of selegiline: Improved bioavailability and selectivity for

MAO-B inhibition. J Neural Transm 2003;110:124-5.

Dobetti L. Fast-melting tablets: Developments and technologies. Pharm

Technol N Am 2001;44-50.

Meyers GL, Battist GE, Fuisz RC. Process and apparatus for making

rapidly dissolving dosage units and product Thereform. PCT Patent

WC 95/34293-A1; 1995.

Allen LV, Wang B. Process for making a particulate support matrix for

making a rapidly dissolving dosage form. US Patent 6,207,199; 2001.

Allen LV, Wang B. Process for making a particulate support matrix for

making a rapidly dissolving tablet. US Patent 5,587,180; 1996.

Allen LV, Wang B, Davis LD. Rapidly dissolving tablet. US Patent

,807,576; 1998.

Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form Indian Pharmacist 2002;1:9-12.

Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P.

The preparation of orally disintegrating tablets using a hydrophilic

waxy binder. Int J Pharm 2004;278:423-33.

Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly

disintegrating tablets manufactured by phase transition of sugar

alcohols. J Control Release 2005;105:16-22.

Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New

method of preparing high-porosity rapidly saliva soluble compressed

tablets using mannitol with camphor: A subliming material. Int J Pharm

;152:127-31.

Eoga AB, Valia KH. Method for making fast-melt tablets. US Patent

,939,091; 1999.

Bonadeo D, Ciccarello F, Pagano A. Process for the preparation of

a granulate suitable to the preparation of rapidly disintegratable

mouth-soluble tablets and compositions obtained thereby. US Patent

,316,029; 1998.

Gregory GK, Ho DS. Pharmaceutical dosage form packages. US Patent

,305,502; 1981.

Yarwood R, Kearnery P, Thompson A. Process for preparing solid

pharmaceutical dosage form. US Patent 5,738,875; 1998.

Lafon L. Galenic form for oral administration and its method of

preparation by lyophilization of an oil-in-water emulsion. US Patent

,616,047; 1986.

Gole DJ, Levinson RS, Carbone J, Davies JD. Preparation of

pharmaceutical and other matrix systems by solid-state dissolution.

US Patent 5,215,756; 1993.

Kaushik D, Dureja H, Saini TR. Orally disintegrating tablets: An overview

of melt-in mouth tablet technologies and techniques. Tablets Capsules

;2:30-6.

Cousin G, Bruna E, Gendrot E. Rapidly disintegratable multiparticular

tablet. US Patent 5,464,632; 1995.

Wehling F, Schuehle S. Base coated acid particles and effervescent

formulation incorporating same. US Patent 5,503,846; 1996.

Wehling F, Schuehle S, Madamala N. Effervescent dosage form with

microparticles. US Patent 5,178,878; 1993.

Amborn J, Tiger V. Apparatus for handling and packaging friable tablets.

US Patent 6,311,462; 2001.

Khankari RK, Hontz J, Chastain SJ, Katzner L. Rapidly dissolving robust

dosage form. US Patent 6,024,981; 2000.

Mizumoto T, Masuda Y, Fukui M. Intrabuccally dissolving compressed

moldings and production process thereof. US Patent 5,576,014;

Mizumoto T, Masuda Y, Kajiyama A, Yanagisawa M, Nyshadham JR.

Tablets quickly disintegrating in the oral cavity and process for

producing the same. US Patent 6,589,554; 2003.

Kovacic M, Milovac J, Cvelbar P, Stalc A, Trost Z, Kopitar Z, et al.

Dispersible cimetidine tablets. US Patent 5,069,910; 1991.

KV Pharmaceutical Company. Drug Delivery Technologies (technical

bulletin) found in part at KV Pharmaceutical Company. Ora Quick.

May 2001.

Dobetti L. (Eurand International), Fast Disintegrating tablets, PCT Patent

WO 99/44580-A1; 1999.

Myers GL, Battist GE, Fuisz RC. Process and apparatus for making

rapidly dissolving dosage units and product there from. PCT Patent

WO 95/34293-A1; 1995.

Cherukuri, et al. Quickly dispersing comestible unit and product. PCT

Patent WO 95/34290-A1; 1995.

Chang RK, Guo X, Burnside B, Couch R. Fast-dissolving tablets. Pharm

Technol 2000;24:52-8.

Morella AM, Pitman IH, Heinicke GW. Taste masked liquid suspensions.

US Patent 6,197,348; 2001.

Alkire TG, Sanftleben RA, Schuehle SS. Taste masking microparticles

for oral dosage forms. US Patent 5,607,697; 1997.

Geoffroy JM, Friend DR, Ng S, Weber TP, Sarabia RE. Taste-masked

microcapsule compositions and methods of manufacture. US Patent

,139,865; 2000.

Friend DR, Ng S, Sarabia Re, Weber TP, Geoffroy JM. Taste-masked

microcapsule compositions and methods of manufacture. US Patent

,139,865; 2000.

Shimuzu T, Sugaya M, Nakano Y, Izutsu D, Mizukami Y, Okochi K, et al.

Formulation study for lansoprazole fast-disintegrating tablet: III, Design

of rapidly disintegrating tablets. Chem Pharm Bull 2003;51:1121-7.

Stroppolo F, Ciccarello F, Milani R, Bellorini L. Oral pharmaceutical

compositions containing cyclodextrins as taste masking agent. WO

Patent 0,241,920; 2002.

Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation

design and optimization of mouth dissolving tablets of nimesulide using

vacuum drying technique. AAPS Pharm Sci Tech 2004;5:Article 36.

Kancke J. Dissolution testing of orally disintegrating tablets. Dissolution

Technologies 2003;10:6-8.

Bi Y, Sunada H, Yonezawa Y, Danjo K, Ostuka A, Iida K. Preparation and

evaluation of a compressed tablet rapidly disintegrating in the oral

cavity. Chem Pharm Bull 1996;44:2121-7.

Dor PJ, Fix JA. Invitro determination of disintegration time of

quick-dissolve tablets using a new method. Pharm Dev Technol

;7:361-71.

Fu Y, Jeong SH, Park K. Preparation of fast dissolving tablets based on

mannose. Polym Mater Sci Eng Preprint 2003;89:821-2.

Mortia Y, Tsushima Y, Yasui M, Termoz R, Ajioka J, Takayama K. Evaluation

of the disintegration time of rapidly disintegrating tablets via a novel

method utilizing a CCD camera. Chem Pharm Bull 2002;50:1181-6.

Narazaki R, Harada T, Takami N, Kato Y, Ohwaki T. A new method for

disintegration studies of rapid disintegrating tablet. Chem Pharm Bull

;52:704-7.

Yang S, Fu Y, Jeong SH, Park K. Application of poly (acrylicacid)

superporous hydrogel microparticles as asuperdisintegrant in fast

disintegrating tablets. J Pharm Pharmacol 2004;56:429-36.

Sunada H, Bi Y. Preparation, evaluation and optimization of rapidly

disintegrating tablets. Powder Technol 2002;122:188-98.

Ozeki T, Yasuzawa Y, Katsuyama H, Takshima Y, Kasai T, Eguchi T, et al.

Design of rapidly disintegrating oral tablets using acid-treated yeast

cell wall: A technical note. AAPS Pharm Sci Tech 2003;4.

Van Scoik KG. Solid Pharmaceutical dosage in tablet triturate form and

method of producing the same. US Patent 5,082,667.

Ahmed IS, Nafadi MM, Fatahallaf A. Formulation of a fast-dissolving

ketoprofen tablet using freeze-drying in blisters technique. Drug Dev

Ind Pharm 2006;32:437-442.

Cilurzo F, Selmin F, Minghetti P, Rimoldi I, Demartin F, Montanari L. Fast-

dissolving mucoadhesive microparticulate delivery system containing

piroxicam. Eur J Pharm Sci 2005;24:355-61.

Sammour OA, Hammad MA, Megrab NA, Zidan AS. Formulation and

Optimization of Mouth Dissolve Tablets Containing Rofecoxib Solid

Dispersion. AAPS PharmSciTech 2006;7:Article 55.

Schiermeier S, Schmidt PC. Fast dispersible ibuprofen tablets. Eur

J Pharm Sci 2002;15:295-305.

Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM. Formulation

and evaluation of fast dissolving tablets of famotidine. Indian Drugs

;42:641-9.

Nandgude TD, Saifee M, Bhise KS. Formulation and evaluation of fast

disintegrating tablets of diphenhydramine tannate. Asian J Pharma

;1:1.

Khan S, Kataria P, Nakhat P, Yeole P. Taste Masking of Ondansetron

Hydrochloride by Polymer Carrier System and Formulation of Rapid-

Disintegrating Tablets. AAPS PharmSciTech 2007;8:Article 46.

Bogner RH, Wilkosz MF. Fast Dissolving tablets:New dosage convenience

for patients. US Pharmacist 2002;27:34-43.




DOI: http://dx.doi.org/10.22377/ajp.v2i1.159

Refbacks

  • There are currently no refbacks.