Pulsatile drug delivery system

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Veena S Belgamwar
Madhuri V Gaikwad
Ganesh B Patil
Sanjay Surana


Pulsatile drug delivery system is the most interesting time- and site-specific system. This system is designed for chronopharmacotherapy which is based on circadian rhythm. The principle rationale for the use of pulsatile release is for
the drugs where a constant drug release, i.e., a zero-order release is not desired. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release period, i.e., lag time. Various systems like capsular systems, osmotic systems, pulsatile system based on the use of
soluble or erodible polymer coating, use of rupturable membranes and pulsatile system based on membrane permeability are summarized in this article.These systems are beneficial for the drugs having chronopharmacological behavior where night time  dosing is required and for the drugs having high first-pass effect and having specific site of absorption in gastrointestinal tract.


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How to Cite
Belgamwar, V. S., Gaikwad, M. V., Patil, G. B., & Surana, S. (2014). Pulsatile drug delivery system. Asian Journal of Pharmaceutics (AJP), 2(3). https://doi.org/10.22377/ajp.v2i3.184


Kikuchi A, Okano T. Pulsatile drug release control using hydrogels. Adv

Drug Deliv Rev 2002;54:53-77.

Rubinstein A, Tirosh B, Baluom M, Nassar T, David A. The rationale

for peptide drug delivery to the colon and the potential of polymeric

carriers as effective tools. J Controlled Release 1995;46:59-73.

Youan BC. Chronopharmaceutics: Gimmick or clinically relevant

approach to drug delivery. J Controlled Release 2004;98:337-53.

Baichwal, Anand R. Woodcook US20050276853, 2005.

Krogel I, Bodmeir R. Pulsatile drug release from an insoluble capsule

body controlled by erodible plug. Pharm Res 1998;15:474-81.

Krogel I, Bodmeir R. Evaluation of enzyme-containing capsular shaped

pulsatile drug delivery system. Pharm Res 1999;19:1424-9.

Krogel I, Bodmeir R. Development of multifunctional matrix drug

delivery system surrounded by an impermeable cylinder. J Controlled

Release 1999;61:43-50.

Percel P, Vishnupad KS, Venkatesh GM. US20036627223B2 2003.

Barzegar-Jalali M, Siyahi-Shadbad M. Design and evaluation of delayed-

release osmotic capsule of acetaminophen. Iran J Pharma Sci Spring


Linkwitz A, Magruder JA, Merrill S. US5318558, 1994.

Niwa K, Takaya T, Morimoto T, Takada K. Preparation and evaluation

of time controlled release capsule made of ethyl cellulose for colon

delivery of drugs. J Drug Targeting 1995;3:83-9.

Maroni A, Zema L, Cerea M, Sangalli ME. Oral pulsatile drug delivery

systems. Exp Opin Drug Deliv 2005;2:855-71.

Conte U, Arsizio B, Manna AL, Comolobo P. US4865849.

Pozzi F, Furlani P, Gazzaniga A, Davis SS. The TIME CLOCK system:

A new oral dosage form for fast and complete release of drug after

predetermined lag time. J Controlled Release 1994;31:99-108.

Fan TY, Wei SL, Yan W. An investigation of pulsatile release tables with

ethylcellulose and Eudrajit L as film coating materials and crosslinked

polyvinyl pyrrolidone in the core tablets. J Controlled Release


Barr IG, Thiel WJ. US5593697.

Bussemer T, Dashevsky A, Bodimeir R. A pulsatile drug delivery system

based on rupturable coated hard gelatin capsules. J Controlled Release


Chen CM. US5260068.

Chen CM. US5508040.

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