Formulation and evaluation of dispersible taste masked tablet of roxithromycin

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Published: Aug 22, 2014
DOI: https://doi.org/10.22377/ajp.v2i2.187

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A S Mundada
D R Meshram
H B Banbale
M R Bhalekar
J G Avari

Abstract

Roxithromycin is a broad spectrum, semisynthetic macrolide antibiotic, having bitter taste. In the present study, an attempt has been made to mask the bitter taste of roxithromycin by complexation technique. Weak cation exchange
resins Indion 214 and Amberlite IRP64, polymer carbopol 934P were used in formulation of complexes with the drug. The loading process was optimized for the pH of loading solution and resin or polymer:drug ratio.The complexes were evaluated
for bulk density, angle of repose, taste masking, and in vitro drug release. In vitro drug release studies showed more than 80% drug release from the optimized formulation within 30 min. Amberlite IRP64 was found to be better complexing agent for masking the bitter taste of roxithromycin.

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How to Cite
Mundada, A. S., Meshram, D. R., Banbale, H. B., Bhalekar, M. R., & Avari, J. G. (2014). Formulation and evaluation of dispersible taste masked tablet of roxithromycin. Asian Journal of Pharmaceutics (AJP), 2(2). https://doi.org/10.22377/ajp.v2i2.187
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Vol. 2 No. 2 (2008): Apr-June
Section
Articles

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References

Dorfner. Ion exchange properties and application. 3rd ed. Ann Arbor

science Publisher; 1972. p. 2.

Borodkin S, Sudanberg DP. Chewable tablets including coated particles

of psudoephedrine-weak cation exchange resin. US patent 1971;

Lange PM. Preparation and use of ion exchange resins loaded with

quinolonecarboxylic acid derivatives. US Patent 1992; 5152986

Avari JG, Bhalekar MR. Cation exchange resin for taste masking and

rapid dissolution of sparfloxacin. Indian drugs 2004;41: 19-23.

Bhalekar MR, Avari JG, Umalkar RA. Preparation and in vitro evaluation

of sustained release drug delivery system for verapamil HCl. Indian J

Pharm Sci 2007;69:418-22.

Bhalekar MR, Avari JG, Umalkar RA, Markandeeywar T. Ion exchange

resin for reduced hygroscopicity of ranitidine HCl. Int J Pharm Excip

;4:121-4.

Borodkin S, Sundberg D. Polycarboxylic acid ion exchange resin,

adsorbates of taste coverage in chewable tablets. J Pharm Sci

;60:1523.