Development of colorimetric method for cephalexin in dosage forms

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Published: Aug 26, 2014
DOI: https://doi.org/10.22377/ajp.v2i2.188

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P Priyanka
P Suresh1

Abstract

Asimple, sensitive, accurate, rapid, and economical colorimetric-spectrophotometric method has been developed for the estimation of cephalexin in capsules. This method is based on the reaction of the drug with ferric chloride and potassium ferricyanide, giving a green-colored chromogen exhibiting maximum absorbance at 791 nm against reagent blank. Beer’s law was obeyed in the concentration range of 1-6 μg/ml. Results of the analysis were validated statistically
and by recovery studies.

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How to Cite
Priyanka, P., & Suresh1, P. (2014). Development of colorimetric method for cephalexin in dosage forms. Asian Journal of Pharmaceutics (AJP), 2(2). https://doi.org/10.22377/ajp.v2i2.188
Issue
Vol. 2 No. 2 (2008): Apr-June
Section
Articles

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References

Budavari S. The merck index. 13th ed. NJ, Whitehouse Station: Merck

and Co., Inc; 2001. p. 339.

Mishra L. Drug today. Delhi: Lorina Publications Inc; 2004. p. 232.

Indian Pharmacopoeia Vol. 1, Government of India, Delhi: The Controller

of Publications; 1996. p. 152.

The United States Pharmacopoeia 26th Rev. Rockville US: Pharmacopoeial Convention, Inc; 2003. p. 395.

British Pharmacopoeia Vol. I. London: Her Majesty’s Stationary Office;

p. 1788.

Barbhaiya R, Turner P. Fluorimetric assay of cephradine, cephalexin and

cephaloglycin. Br J Clin Pharmacol 1977;4:427-31.

Squella JA, Nunez-Vergara LJ, Gonzalez EM. Polarographic analysis of

cephalexin. J Pharm Sci 1978;67:1466-7.

Fabregas JL, Beneyto JE. Simultaneous determination of cephalexin and

lysine in their salt using high-performance liquid chromatography of

derivatives. J Pharm Sci 1980;69:1378-80.

Al-Momani IF. Spectrophotometric determination of selected

cephalosporins in drug formulations using flow injection analysis. J

Pharm Biomed Anal 2001;25:751-7.

Coran SA, Bambagiotti-Alberti M, Giannellini V, Baldi A, Picchioni G,

Paoli F. Development of a densitometric method for the determination

of cephalexin as an alternative to the standard HPLC procedure. J Pharm

Biomed Anal 1998;18:271-4.

Agbaba D, Eric S, Zivanov SD, Vladimirov S. HPTLC assay of cephalexin and cefaclor in pharmaceuticals. Biomed Chromatogr 1998;12:133-5.

Wu ZJ, Guo WB, Zhang QG, Ni KY, Lin YS. Studies on the simultaneous

measurement of several cephalosporins by RP-HPLC. Se Pu

;17:518-21.

Sanford B. Pharmaceutical statistics: Practical and clinical application.

New York: Marcell Dekker; 2004. p. 173-228.

Pasteelnick LA. Analytical methods validation. In: Berry R, Robert NA,

editors. Pharmaceutical process validation. New York: Marcell Dekker;

p. 411-28.

Edwardson PA, Bhaskar G, John E. Method validation in pharmaceutical

analysis. J Pharm Biomed Anal 1990;8:929-33.

Carr GP, Wahlich JC. A practical approach to method validation in

pharmaceutical analysis. J Pharm Biomed Anal 1990;8:613-8.

Ciurczak EW. Validation of spectroscopic methods in pharmaceutical

analysis. Pharma Tech 1998;64-70.