Designing of superporous cross-linked hydrogels containing acrylic-based polymer network
Main Article Content
Abstract
FT-IR, 1H-NMR, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA) studies of the copolymer along with homopolymers were carried out. FT-IR studies showed no interactions on copolymerization. SEM studies of the
copolymer were carried out and mean particle size was found to be 50 μm. TGA analysis indicated an increase in thermal stability by cross-linking the polymer network. Swelling behavior of the copolymer showed more swelling by increasing pH of the medum and the prepared polymer was found to be biodegradable. The prepared cross-linked polymer system holds good for further drug delivery studies in connection to its super swelling and biodegradability.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv
Rev 2002;43:3-12.
Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in
pharmaceutical formulations. Eur J Pharm Biopharm 2000;50:27-46.
Kikuchi A, Okano T. Pulsatile drug release control using hydrogels. Adv
Drug Deliv Rev 2002;43:53-77.
Habsuda J, Simon GP, Cheng YB, Hewitt D. Chemical structure of
composites derived from poly (silicic acid) and 2-hydroxy ethyl
methacrylate. DRJ Polym Sci Part A Polym Chem 2001;39:1342.
Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv
Drug Deliv Rev 2001;53:321-39.
Mastschke C, Isele U, Van Hoogevest P, Fahr A. Sustained-release
injectables formed in situ and their potential use for veterinary
products. J Control Release 2002;85:1-15.
Wei G, Xu, H, Ding PT, Li SM, Zheng JM. Thermosetting gels with
modulated gelation temperature for ophthalmic use: The rheological
and gamma scintigraphic studies. J Control Release 2002;83:65-74.
Miyazaki S, Suisha F, Kawasaki A, Shirakawa M, Yamatoya K, Attwood D. Thermally reversible xyloglucan gels as vehicles for rectal drug delivery.J Control Release 1998;56:75-83
Carelli V, Coltelli S, Colo G, Nannipieri E, Serafini MF. Silicone
microspheres for pH-controlled gastrointestinal drug delivery. Int J
Pharm 1999;179:73-83.
Dziubla TD, Torjman MC, Joseph JI. Evaluation of porous networks of
poly(2-hydroxyethyl methacrylate) as interfacial drug deliverydevices.
Biomaterials 2001;22:2893-9.
Sen M, Uzun C, Guven O. Controlled release of terbinafine hydrochloride from pH sensitive poly (acrylamide-maleic acid) hydrogels. Int J Pharm 2000;203:149-57.
Negishi M, Hiroki A, Miyakojima Y, Asano M, Kalakai R, Yoshida M.
Swelling and ketoprofen release characteristics of thermo and ph
responsive copolymer gels. Drug Dev Ind Pharm 1999;25:437-44.
Ganorkar CR, Liu F, Baudys M, Kim V. Modulating insulin-release profile
from pH-thermosensitive polymeric beads through polymer molecular
weight. J Control Release 1999;59:287-90.
Viroonchatapam E, Sato H, Ueno M, Adachi I, Tazawa K, Horikhosi I.
Release of 5-fluorouracil from thermosensitive magnetoliposomes
induced by an electromagnetic field. J Control Release 1997;46:263.
Dinarvand R, D’Emaniele A. Preparation, characterisation, and
drug release from thermoresponsive microspheres. Int J Pharm
;118:237.
D’Emanuele A, Dinarvand R. The use of thermoresponsive hydrogels
for on-off release of molecules. J Control Release 1995;36:221.
Nicolic L, Skal D, Nicolic V, Stamen Scovic J, Babic D, Stojanovic S. Methyl methacylate and acrylamide crosslinked macroporous copolymers.
J Appl Polym Sci 2004;91:387.