Formulation and evaluation of melt-in-mouth tablets of haloperidol

Article Sidebar

PDF
Published: Aug 28, 2014
DOI: https://doi.org/10.22377/ajp.v2i4.193

Main Article Content

Sajal Kumar Jha
Vijayalakshmi P
Roopa Karki
Divakar Goli

Abstract

Haloperidol, a butyrophenone, is widely used neuroleptic.Though haloperidol is well absorbed after oral dosing, there is a first pass metabolism leading to a reduced bioavailability of the drug (60-70%).Therefore, the present investigation is concerned with the development of melt-in-mouth tablets of haloperidol.Various formulations were prepared incorporating a combination of superdisintegrants, croscarmellose sodium, sodium starch glycolate, and crospovidone by direct compression method.The formulated melt-in-mouth tablets were evaluated for various physicochemical parameters, disintegration time
and for in vitro drug release. All the formulations had disintegration time less than 30 s and release maximum amount of drug by 12 min. Formulation containing higher concentration of crospovidone decreases disintegration time and optimize the drug release. The most satisfactory formulation was found to be stable during the stability studies conducted as per ICH guidelines QIC, as it showed no significant changes (P<0.05) in the physicochemical properties, disintegration time and in vitro drug release.

Downloads

Download data is not yet available.

Article Details

How to Cite
Jha, S. K., P, V., Karki, R., & Goli, D. (2014). Formulation and evaluation of melt-in-mouth tablets of haloperidol. Asian Journal of Pharmaceutics (AJP), 2(4). https://doi.org/10.22377/ajp.v2i4.193
Issue
Vol. 2 No. 4 (2008): Oct-Dec
Section
Articles

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

References

van Schaick EA, Lechat P, Remmerie BM, Ko G, Lasseter KC, Mannaert

E. Pharmacokinetic comparison of fast-disintegrating and conventional

tablet formulations of risperidone in healthy volunteers. Clin Ther

;25:1687-99.

Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Lida K. Preparation and

evaluation of a compressed tablet rapidly disintegrating in oral cavity.

Chem Pharm Bull 1996;44:2121-7.

Keith S. Advances in psychotropic formulations. Prog uropsychopharmacol Biol Psychiatry 2006;30:996-1008..

Sharma S, Garg R, Naruka PS, Gupta GD. Fast dissolving tablet: The

future of compaction. Pharmainfo.net, 2007.

Babu GV, Kumar NR, Himasankar K, Seshasayana A, Murthy KV.

Nimesulide-modified gum karaya solid mixtures: Preparation,

characterization and formulation development. Drug Dev Ind Pharm

;29:855-64.

Chowdary KP, Hemavathy R. Formulation and dissolution rate studies on

dispersible tablets of ibuprofen. Indian J Pharm Sci 2000;63:213-6.

Rama Rao N, Chowdary KP. Improvement of dissolution rate and

bioavailability of Piroxicam with pre-gelatinized starch. Indian J Pharm

Sci 2001;63:36-40.

Rizk S. Investigation on a new modified USP Xanthan with tablet

disintegration properties. Drug Dev Ind Pharm 1997;23:19-26.

Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation

design and optimization of mouth dissolving tablets of niimesulide

using vacuum drying technique. AAPS Pharm Sci Tech 2004;5:36.

Panigrahi D, Baghel S, Mishra B. Mouth dissolving tablets: An overview

of preparation techniques, evaluation and patented technologies. J

Pharma Res 2005;4:33-8.

Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Edu

;35:150.

ndian Pharmacopoeia. 4th ed. Controller of Publications. India, New

Delhi: 1996. p. 80,

Chaudhary PD, Chaudhary SP, Lanke SD. Formulation and evaluation

of taste masked Orodispersible dosage form of levocetrizine

dihydrochloride. Indian J Pharm Edu Res 2007;41:319-28.

Available from: http://www.ich.org/cache/compo/363-272-1.html.

/11/1996.