Preparation and evaluation of delayed release aceclofenac microspheres
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Abstract
propyl methyl cellulose phthalate (HPMCP), Eudragit L 100, and Eudragit S -100 on the release of aceclofenac from the CAP microspheres have been evaluated.The microspheres were characterized for particle size, scanning electron microscopy (SEM), percentage yield, drug entrapment, and for in-vitro release kinetics. The shape of microspheres was found to be spherical by SEM. The drug entrapment efficiency of microspheres was found to be ranging from 75.65 to 96.52 %w/w. The study was designed in the form of a factorial design in which the effects of HPMCP, Eudragit L 100, and Eudragit S 100 on the release rate of drug from CAP delayed release microspheres were evaluated. The results revealed that the HPMCP exhibits positive influence whereas Eudragit L 100 and Eudragit S 100 exhibits negative effect on the drug release rate of CAP microspheres. In vitro drug release from all formulations followed the first order release kinetics and erosion plot. Formulation with drug: CAP : HPMCP ratio of 1:8:2 was considered best because it showed delayed release.
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References
Bolton S. Pharmaceutical statistics. 2 ed. New York: Marcel Dekker
Inc; 1984. p. 266-8.
Wan LS, Chui WK. Deviation of the ratio of drugs in a two component
mixture encapsulated in cellulose phthalate microspheres. J
Microencapsul 1995;12:417-23.
Adi LA, Bassam A, Madi J, Malek E, Rebal S, Rula A. Development of
sustained-release ibuprofen microspheres using solvent evaporation
technique. Archiv der Pharmazie 1999;11:405-7.
Lorenzo ML, Remunan C, Vila JL, Alonso MJ, Design of microencapsulated
chitosan microspheres for colonic drug deliver y. J Control
Release 1998;52:109-18.
Mutalik S, Naha A, Usha AN, Ranjith AK, Musmade P, Manoj K, et
al. Preparation, in-vitro, preclinical and clinical evaluations of once
daily sustained release tablets of aceclofenac. Arch Pharm Res
;30:222-34.
Dashora K, Saraf S, Swarnalata S. Effect of processing variables on
microparticulate system of aceclofenac. Pak J Pharm Sci 2006;19:1-65.
Aceclofenac 100mg Tablets, Medicines and health care products
regulatory agency. PL 04416/0591.
Tamizharasi S, Rathi JC, Rathi V. Formulation, characterization and
in-vitro release kinetics of aceclofenac loaded poly (ε-caprolactone)
microspheres. Indian Drugs 2007;44:973-5.
Patil SS, Kasture PV. Studies on preparation and evaluation of
biodegradable poly (lactide-co-glyoclide) microsphere of aceclofenac,
Cmu. J Nat Sci 2007;6:195-206.
Upadhye K, Bakhles D. Preparation and evaluation of gelatin
microspheres containing ciprofloxacin hydrochloride. Indian Drugs
;26:665-9.
Grass GM 4th, Banker GS, Rhodes CT. Modern pharmaceutics. 2nd ed.
New York: Marcel Dekker Inc; 1990. p. 654-5.