Effect of cross-linking agent on the characteristics of celecoxib loaded chitosan microspheres
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Abstract
microspheres were prepared by emulsification cross-linking method. Microspheres were characterized for entrapment efficiency, particle size, in-vitro drug release and surface morphology was studied by scanning electron microscopy. The
entrapment efficiency of the glutaraldehyde and formaldehyde cross-linked microspheres was significantly higher (P<0.05) than the heat-cross-linked microspheres. In-vitro drug release studies indicated that the microspheres cross-linked using glutaraldehyde showed slower release rate than those cross-linked with formaldehyde while the heat cross-linked microspheres showed the fastest release.
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