Development, characterization and solubility study of solid dispersion of terbinafine hydrochloride by solvent evaporation method

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Published: Aug 28, 2014
DOI: https://doi.org/10.22377/ajp.v2i3.211

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Narendra Kumar
Akhilesh K Jain
Chhater Singh
Rajesh Kumar

Abstract

Terbinafine HCl (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Terbinafine HCl by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 using solvent evaporation methods. FT- IR spectra revealed no chemical incompatibility between drug and polyvinyl pyrrolidone K30. Drug-polymer interactions were
investigated using differential scanning calorimetry (DSC), Powder X-Ray Diffraction (PXRD).

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How to Cite
Kumar, N., Jain, A. K., Singh, C., & Kumar, R. (2014). Development, characterization and solubility study of solid dispersion of terbinafine hydrochloride by solvent evaporation method. Asian Journal of Pharmaceutics (AJP), 2(3). https://doi.org/10.22377/ajp.v2i3.211
Issue
Vol. 2 No. 3 (2008): Jul-Sep
Section
Articles

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