Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride

Article Sidebar

PDF
Published: Aug 25, 2014
DOI: https://doi.org/10.22377/ajp.v2i3.212

Main Article Content

Kovur Purushotham
M D Najmuddin
B Satyanath

Abstract

The present study was aimed for the development and evaluation of hydrotropic starch gels of terbinafine hydrochloride which is an allylamine derivative of antifungal agent was formulated by using corn starch and sodium salicylate as
hydrotropic salt. The gels were prepared in presence and absence of propylene glycol. The prepared gels were evaluated for in vitro drug release, rheological behavior and microbial studies. The degree of increase in the drug diffusion was found to be in order corn starch gel with propylene glycol was greater than corn starch gel without propylene glycol. The microbial studies were carried out in soya bean casein digest medium with Candida albicans as test organisms and were found to be 22.86 ± 0.58 and 20.22 ± 0.65 mm for TCSG (IV) and TCS (III), respectively. All the gels exhibited shear thinning. The
rheogram indicated that the gel systems are pseudoplastic and exhibited thixotropy. The added propylene glycol has not
appreciably altered the apparent viscosity values.

Downloads

Download data is not yet available.

Article Details

How to Cite
Purushotham, K., Najmuddin, M. D., & Satyanath, B. (2014). Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride. Asian Journal of Pharmaceutics (AJP), 2(3). https://doi.org/10.22377/ajp.v2i3.212
Issue
Vol. 2 No. 3 (2008): Jul-Sep
Section
Articles

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

References

Darwish A, Florence AT, Saleh AM. Effects of hydrotropic agents on the

solubility, precipitation and protein binding of etoposide. J Pharma Sci

;78:577-81.

Agrawal S, Pancholi SS, Jain NK, Agrawal GP. Hydrotropic

solubilization of nimesulide for parenteral administration. Int J

Pharma 2004;274:149-55.

Maheshwari RK, Chavda V, Sahoo K, Varghese S. Novel application of

hydrotropic solubilization in the spectrophotetri analysis of diclofenac

sodium in solid dosage form. Asian J Pharma 2006;1:30-2.

Maheshwari RK, Ajmera A. Novel application of hydrotropic

solubilization in the spectrophotetri analysis of diclofenac sodium in

solid dosage form. Asian J Pharma 2006;1:60-2.

Sweetman, Sean C. Martindale: The complete drug reference. 33rd ed.

p. 394-1.

Richard P, Howland M, Harvey A. Lippincotts Illustrared Pharmacology.

rd ed. p. 410-1.

Cooper and Gunn’s “Dispensing for pharmacutical students, 12th ed.

CBS Publication and Distributors; 2000. p. 29,92,207.

Indian Pharmacopaeia. Delhi: Controller of Publication; 1996. p. 701.

Brittain HG. Analytical profiles of drug substances and excipients.

Academic press, An umprint of Elsevier; 2005. p. 427.

British Pharmacopoeia. Compound Benzoic acid ointement,

;2:697.

Casson N. A flow equation for pigment oil suspension of the printing

ink type-in Rheology of dispersers systems. In: Mill CC, editor. London:

Pergamon Press; 1959. p. 84.

Pharmacopoeia of India. vol 2. Delhi: Controller of Publications; 1985.

p. A107.