Effect of penetration enhancers on the permeability characteristics of lisinopril transdermal delivery systems
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Abstract
average about 25% of the drug is absorbed after administration of a single dose.Thus, a controlled drug delivery formulation of lisinopril for transdermal absorption would be more advantageous and beneficial for improving the bioavailability and reducing the frequency of administration for long-term treatment. Matrix type transdermal films were prepared by solvent
casting technique using a combination of ammonia methacrylate copolymer, type A. USP/NF( EudragitRL100) and poly vinyl pyrrolidone (PVP) as polymers. Propylene glycol was used as plasticizer. Glycerine, dimethyl sulphoxide (DMSO)
and span-60 were used as penetration enhancers. The physicochemical parameters like thickness, folding endurance, drug content, tensile strength and stability were evaluated. In- vitro drug release and in-vitro skin permeation studies were carried
out using modified Keshary-Chien permeation cell. Infra-red spectroscopy (IR) and differential scanning colorimetry (DSC) were performed to follow drug carrier interactions. In- vitro drug permeation profile of the formulated films showed that
formulations containing span-60 as penetration enhancer (F4, F8, F12, F16, F20) showed highest drug permeation. From the results of this study it indicated that the permeation of lisinopril from films containing span-60 as penetration enhancer
was the best at all polymer ratios as compared to the films containing DMSO and glycerine. The order of permeability enhancement from the films was found to be span-60 > DMSO > glycerine. There was no significant difference in the
physicochemical characters and drug content for a period of 3 months.
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References
Martindale. The Complete Drug Reference. 34th ed. Great Britain: The
Pharmaceutical Press; 2005. p. 946-7.
Available from: http://www.ncbi.nlm.nih.gov/pubmed/2844497. [Last
accessed on 2010 Mar 20].
Wongpayakul L. Effect of single and combined permeation enhancers on
the skin permeation of ketoprofen transdermal drug delivery system.
CMU Journal 2006;5:41-51.
Banweer J, Pandey S, Pathak AK. Formulation, optimisation and
evaluation of matrix type transdermal system of lisinopril dihydrate
using permeation enhancers. JPR 2008;1:16-22.
Ahmed GM, Charyulu NR, Harish NM, Prabhu P, Roopesh PT. Polymeric
strips containing sparfloxacin for the long term treatment of
periodontitis. IJPR 2008;1:48-53.
Krishnaiah YS, Satyanarayana V, Bhaskar P. Influence of limonene on
the bioavailability of nicardipine hydrochlorothiazide from membrane
modulated transdermal therapeutic systems in human volunteers. Int
J Pharm Krishnaiah 2002;247:91-102.
Bijaya G, Harivardhan RL, Raghvendra VK, Jasmina K. Comparison of
skin permeability of drugs in mice and human cadaver skin. Indian J
Exp Biol 2000;38:42-5.
Katkam RR, Chakkapan S, Gandhi K, Thomas S, Puri CP, Shrivastava
R. Studies in transdermal drug delivery system for Estrodial. Indian J
Pharm Sci 1994;56:121-5.
Das MK, Bhattacharya A, Ghosal SK. Transdermal delivery of trazodone
hydrochloride from acrylic films prepared from aqueous latex. Indian
J Pharm Sci 2006;68:41-6.
Murthy TE, Mallikarjuna RP, Murali K. Design and development of
piroxicam transdermal films. Pharmacol Rev 2004;56:145-7.
Hiremath SP, Manvi FV, Sreelakshmi S. Formulation, characterisation
and evaluation of transdermal patches of diltiazem hydrochloride. Ind
Drugs 2010;47:41-7.
Swamy NG, Dharmarajan TS, Paranjothi KL. Study of film forming
properties of hydroxy propyl guar and its use in preparation of
medicated transdermal patches. IJPER 2008;42:147-52.
Saxena M, Mutalik S, Reddy MS. Formulation and evaluation of
transdermal patches of metoclopramide hydrochloride. Ind Drugs
;43:740-5.
Kulkarni SV, Kumar RP, Patel N, Ramesh B, Rao SR, Kumar AP.
Development and evaluation of diltiazem hydrochloride transdermal
patches by using glycerol and castor oil as plasticisers. Research J Pharm
and Tech 2010;3:905-9.
Tanwar YS, Chauhan CS, Sharma A. Development and evaluation of
carvedilol transdermal patches. Acta Pharm 2007;57:151-9.
Bhalla HL, Gadkari SJ. Transdermal films of isosorbide dinitrate. Ind
Drugs 1987;24:313-5.
Shah HS, Tojo K, Chien YW. T0 Transdermal controlled delivery of
verapamil: Characterization of in vitro skin permeation. Int J Pharm
;86:167-73.
Squillante E, Needham T, Zia H. Solubility and in vitro transdermal
permeation of nifedipine. Int J Pharm 1997;159:171-80.
Ghosh TK, Adir J, Xiang S, Onyilofur S. Transdermal delivery of
Metoprolol II: In vitro skin permeation and bioavailability in hairless
rats. J Pharm Sci 1995;84:158-60.