Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation

Gupta Anish Kumar, Siddiqui Abdul Wadood, Maurya Sheo Datta, Dhakar Ramchand


The aim of this study was to develop a controlled release system targeting antibiotic delivery to the stomach. The hydrogels were synthesized by using chitosan, poly (acrylic acid) and poly (vinyl pyrrolidone) polymers crosslinked
with glutaraldehyde and N,N’-methylenebisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were prepared by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly (acrylic acid), poly (vinyl pyrrolidone) and N,N’-methylenebisacrylamide were kept constant in all formulations. The effect of glutaraldehyde concentration on the swelling and release characteristics were evaluated. Modalities used to assess the most optimal hydrogel formulation included high liquid chromatography, FTIR analysis, differential scanning calorimetry, swelling studies, in vitro drug release study, mucoadhesive study and scanning electron microscopy. The result showed that IPN hydrogels were greater in swelling, more mucoadhesive and released more drug at lower pH values. Thus, it is believed that the antibiotic
concentration in the stomach might be sustained through this formulation.

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Risbud MV, Hardikar AA, Bhat SV, Bhonde RR. pH-sensitive freeze-dried

chitosan-polyvinyl pyrrolidone hydrogels as controlled release system

for antibiotic delivery. J Control Release 2000;68:23-30.

Sema E, Dursun S. Synthesis, characterization and evaluation of IPN

hydrogels for antibiotic release. Drug Deliv 2004;11:381-8.

Khurma JR, Nand AV. Temperature and pH sensitive hydrogels composed of chitosan and poly (ethylene glycol). Polymer Bull 2008;59:805-12.

Lee YM, Kim SH, Cho CS. Synthesis and swelling characteristics of pH

and thermo-responsive interpenetrating polymer network hydrogel

composed of poly (vinyl alcohol) and poly (acrylic acid). J App Poly Sci


Shantha KL, Harding DR. Preparation and in-vitro evaluation of poly

[N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate]-chitosan

interpolymeric pH-responsive hydrogels for oral drug delivery. Int J

Pharm 2000;207:65-70.

Chowdary KP, Rao YS. Mucoadhesive microcapsules of glipizide:

Characterization, in-vitro and in-vivo evaluation. Indian J Pharm Sci


Chun MK, Sah H, Choi HK. Preparation of mucoadhesive microspheres

containing antimicrobial agents for eradication of H.pylori. Int J Pharm


Yong Q, Park K. Environmental-sensitive hydrogels for drug delivery.

Ad Drug Del Rev 2001;53:321-39.

Kim SJ, Park SJ, Kim SI. Synthesis and characterization of interpenetrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(N-isopropylacrylamide). React Funct Polym 2003;55:61-7.

Miyazaki S, Kubo W, Attwood D. Oral sustained delivery of theophylline

using in-situ gelation of sodium alginate. J Control Release 2000;67:275-80.

Torre PM, Enobakhare Y, Torrado G, Torrado S. Release of amoxicillin

from polyionic complexes of chitosan and poly (acrylic acid), study of

polymer/polymer and polymer/drug interaction within the network

structure. Biomaterials 2003;24:1499-506.

Sahin S, Selek H, Ponchel G, Ercan MT. Preparation, characterization and in vivo distribution of terbutaline sulfate loaded albumin microspheres.

J Control Rel 2002;82:345-58.

Raymond G, Degennaro M, Mikeal R. Preparation of gelatin phenytoin

sodium microspheres: An in-vitro and in-vivo evaluation. Drug Dev Ind

Pharm 1990;16:1025-51

Gupta N, Srivastava AK. Interpenetrating polymer networks: A review

in synthesis and properties. Poly Int 2003;35:109.

Hoffman AS. Hydrogels for biomedical applications. Adv Drug Del Rev


Lin CC, Metters AT. Hydrogels in controlled release formulations:

Network design and mathematical modeling. Ad Drug Del Rev


Yadav KS, Satish CS, Shivakumar HG. Preparation and evaluation of

chitosan-poly(acrylic acid) hydrogels for stomach specific delivery

for amoxicillin and metronidazole. Indian J Pharm Sci 2007;69:91-5.

Bumsang K, Youngchan S. pH-sensitive swelling and release behaviours of anionic hydrogels for intelligent drug delivery system. J App poly Sci 2007;105:3656-61.



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