Formulation and evaluation of buccoadhesive tablets of clotrimazole

Tahvilian Reza, Moosavi S Sara

Abstract


The buccoadhesive tablet is one of delivery systems that can be used for different drugs in order to improve the efficacy of drugs in patients. Hydrophilic polymers are using to prepare these types of tablets with appropriate adhesion and
stability in order to deliver the drug for a period of time and also in a specific place in month.The purpose of the study was to formulate and evaluate mucoadhesive buccal tablets of clotrimazole.The tablets were evaluated for weight variation, hardness, friability, disintegration, content uniformity, surface pH, mucoadhesive strength, swelling index and in vitro drug release.
Increasing hydroxypropylmethylcellulose (HPMC) concentration resulted in decreasing the swelling index and increasing surface pH.The surface pH of all tablets was found to be satisfactory, close to neutral pH; hence, no irritation would observe with these tablets.The maximum bioadhesive strength was observed in tablets formulated with high content of HPMC. Lower release rates were observed by increasing the content of HPMC in the formulation The in vitro release results demonstrated that drug is released by non-Fickian diffusion mechanism with zero-order kinetics.


Full Text:

PDF

References


Ellepola AN, Samaranayake LP. Antimycotic agents in oral candidiasis:

an overview: 1, Clinical variants. Dent Update 2000;27:111-6.

Albougy HA, Naidoo S. A systematic review of the management of oral

candidiasis associated with HIV/AIDS. SADJ 2002;57:457-66.

Pienaar ED, Young T, Holmes H. Interventions for the prevention and

management of oropharyngeal candidiasis associated with HIV infection

in adults and children. Cochrane Database Syst Rev 2006;3:CD003940.

Anaissie E. Opportunistic mycoses in the immunocompromised host:

Experience at a cancer center and review. Clin Infect Dis 1992;14:S43-53.

Taneri F. Improvement in the physicochemical properties of

ketoconazole through complexation with cyclodextrin derivatives.

J Incl Phenom Macrocycl Chem 2002;44:257-60.

Udgirkar DB, Hiremath SN, Sreenivasa K, Pawar D. Formulation and

in vitro evaluation of buccoadhesive tablets containing ketoconazole

inclusion complex with β-cyclodextrin. J Pharm Tech 2009;2:396-404.

Jug M, Becirevic-Lacan M. Influence of hydroxypropyl cyclodextrin

complexation on piroxicam release from buccoadhesive tablets. Eur J

Pharm Sci 2004;21:251-60.

Singh S, Jain S, Muthu MS, Tiwari S, Tilak R. Preparation and evaluation

of buccal bioadhesive films containing clotrimazole. AAPS Pharm Sci

Tech 2008;9:660-7.

Martin MV. Antifungal agents. In: Samaranayake LP, MacFarlane TW,

editors. Oral Candidiasis. London: Butterworth and Co; 1990, p. 238-59.

Plempel M, Bartmann K, Buchel KH, Regel E. A new orally applicable

antifungal substance with broadspectrum activity. Antimicrob Agents

Chemother 1969;69:271-4.

Bouckaert S, Remon JP. In-vitro bioadhesion of a buccal, miconazole

slow release tablet. J Pharm Pharmacol 1993;45:504-7.

Save T, Venkitachalam P. Buccoadhesive tablets of nifedipine in

standardization of a novel buccoadhesive erodible carrier. Drug Dev

Ind Pharm 1994;20:3005-14.

Belgamlwar VS, Surana SJ. Floating bioadhesive drug delivery system

using novel effervescent agents. Asian J Pharm 2009;13:156-60.

Khanna R, Agarwal SP, Ahuja A. Preparation and evaluation of

bioerodible buccal tablets containing clotrimazole. Int J Pharm

;138:67-73.




DOI: http://dx.doi.org/10.22377/ajp.v4i4.228

Refbacks

  • There are currently no refbacks.