Formulation and in vitro characterization of alginate microspheres loaded with diloxanide furoate for colon- specific drug delivery
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Abstract
Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency, and in vitro drug release in simulated gastrointestinal fluids. XRD and differential scanning calorimetery were used to confirm successful
entrapment of DF into the alginates microspheres. All the microsphere formulations showed good % drug entrapment (73.82±1.99). Calcium alginate retarded the release of DF at low pH (1.2 and 4.5) and released microspheres slowly at pH 7.4 in the colon without colonic enzymes.
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