Behavior of suspending and wetting agents in aqueous environment

Article Sidebar

PDF
Published: Aug 25, 2014
DOI: https://doi.org/10.22377/ajp.v3i1.234

Main Article Content

Shashikant C Dhawale
Sudhir G Wadodkar
Avinash K Dorle

Abstract

This work describes the changes in viscosity, conductivity, pH, electrical conductivity, dielectric constant, zeta potential,
UV, and IR spectra of aqueous solutions/dispersions of sodium carboxy methyl cellulose (CMC), Tween 80, and sodium
lauryl sulphate (SLS) during aging at different temperatures. Significant reduction in viscosity ofh sodium CMC occurred
during aging studies, while relatively small decrease in viscosity was seen with Tween 80 and SLS. Increment in specific
conductivity was seen with aging of excipients. Significant increase of zeta potential was also seen with aging of samples.
Concomitant shift in IR spectra of samples was observed with aging at 40°C.

Downloads

Download data is not yet available.

Article Details

How to Cite
Dhawale, S. C., Wadodkar, S. G., & Dorle, A. K. (2014). Behavior of suspending and wetting agents in aqueous environment. Asian Journal of Pharmaceutics (AJP), 3(1). https://doi.org/10.22377/ajp.v3i1.234
Issue
Vol. 3 No. 1 (2009): Jan-Mar
Section
Articles

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

References

Hussain MA, August BJ, Maynn MB, Wu LS. Injectable suspensions for

prolonged release of nalbuphine. Drug Dev Ind Pharm 1991;17:67-76.

Aniley W, Paul JW. Handbook of Pharmaceutical excipients. 2nd ed. A

Joint publication of Amer Pharm Asso and the Pharm Society of Great

Britain; 1994. p. 76-81.

Caramella C, Cocchi GA, Catellani P, Colomo U, La Manna A, The

effect of some wetting agents on the characteristics of suspensions

of sulphamethoxypyridazine and its N’- acetyl derivative. Es Da Boll

Chim Farma 1976;115:658.

Kuprina NA, Blagovidova YA, Knizhnik AZ. Production and investigation

of sulphamethoxine suspension with various stabilizers. Farmatsiya

;24:27-30.

Muzik M, Turan J, Stachova J. Effect of aerosil and Tween 80 on the

stability of a suspension of zinc oxide and talc. Ceska a Slovenska

Farmacie 1990;39:1-3.

Hunter RJ. Zeta potential in Colloid Science, Academic, New York:

Zatz JL, Berry J, Alderman DA. Pharmaceutical dosage forms, Disperse

Systems. Vol. 2. Marcel Dekker Inc.; 1984. p. 75.

Zatz JI, Ip BK. Stabilization of oil-in-water emulsions by gums. J Soc

Cosmet Chem 1986;37:329-50.

Zatz JL, Knapp K. Viscosity of xanthan gum solutions at low shear rates.

J Pharm Sci 1984;73:468-71.

Calcinari R. Zeta potential and its importance in pharmaceutical

technology. Farmaco Ed Prat 1970;25:24-38.

Carvalho FD, Nogueira PL, Ramos MR, Cancelo CA. Determination

of the dielectric requirement and the solubility parameter of 1,4-

benzodiazepines. Anales de la Real Academia de Farmacia (Spain)1990;56:493-501.