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remained intact up to pH 3.0, disintegrated at pH 7.2, and released up to 12 hours. The ideal batch (1:3) showed minimum release at pH 1.2 and maximum release at pH 6.8, and an increased amount of curcumin in the blood stream(1.287 Î¼g/ml)
was achieved when compared with pure curcumin (0.5 Î¼g/ml). The drug release was retarded by the high concentrationand greater thickness of the coating of HPMC on the pellets. Release kinetics of the preparation shows a non-Fickian or
anamolous diffusion or matrix erosion.
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