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concentration was increased. It was also found that as the concentration of the alcohol was increased, the viscosity of the microemulsion decreased. After the identification of the microemulsion region, the composition of the microemulsion was fixed at oil 9-10%, Smix 35-40% and water 45-50%.The formulated microemulsion was evaluated for various parameters like pH, conductivity, zeta potential, viscosity and in vitro drug diffusion studies. All the evaluation parameters showed satisfactory
results. Using this microemulsion, the solubility of valproic acid was increased from 1.29 to 36 mg/ml. Diffusion studies
have shown a lag period of 45 min. Thirteen percent drug diffusion was achieved in 3 h. The prepared microemulsion was
stable at 40Â°C and 75% relative humidity.
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