Preparation and in vitro release of hydrochlorothiazide from gellan beads produced by ionotropic gelation

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Published: Aug 25, 2014
DOI: https://doi.org/10.22377/ajp.v3i2.258

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M O Emeje
N E Eni-ike
S A Brown
S I Ofoefule

Abstract

The inherent property of gellan gum to gel and form circular beads through a process of ionotropic gelation in the presence of cations was utilized in the formulation of hydrochlorothiazide (HCTZ).The prepared beads exhibited good drug entrapment efficiency, content uniformity, and sustained release potential. The gelatin-HCTZ beads could be utilized in the delivery of HCTZ, by which reduced frequency of the drug administration could be achieved.

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How to Cite
Emeje, M. O., Eni-ike, N. E., Brown, S. A., & Ofoefule, S. I. (2014). Preparation and in vitro release of hydrochlorothiazide from gellan beads produced by ionotropic gelation. Asian Journal of Pharmaceutics (AJP), 3(2). https://doi.org/10.22377/ajp.v3i2.258
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Vol. 3 No. 2 (2009): Apr-June
Section
Articles

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References

Kuo MS, Mort AJ, Dell A. Identification and location of L-glycerate, an

usual acyl substituent in gellan. Carbohy Dr. Res 1983;156:173-87.

Sanderson GR, Clark RC. Gellan gum. Food Technol. 1983;37:62-70.

Alhaique F, Santucci E, Carafa M, Coviello T, Murtas E, Riccier FM.

Gellan in sustained release formulations, preparation of gel capsules

and release studies. Biomaterials 1996;17:1981-6,

Ike-Uno U, Ofoefule SI Chukwu A. Evaluation of gellan gum as a potentialpharmaceutical adjuvant: Binding properties in tablets containing

poorly water soluble and poorly compressible drug. J Drug Deli Sci

Tech 2006;16:397-401.

Miyazaki S, Aoyama H, Kawasaki N, Kubo W, Attwood D. In situ-gelling gellanformulations for oral drug delivery. J Control Release 1999;60:287-95.

Paulson M, Edsman K. Controlled drug release from gels using surfactantaggregates: 1. Effect of Lipophilic interactions for a series unchargedsubstances. J Pharm Sci 2000;190:1216-25.

Franklin-Ude PI, Emeje MO, Ofoefule SI. Evaluation of Gellan Gum as

a Granulating Agent for Chloroquine Phosphate Tablets. Journal of

Pharmacology and Toxicology 2008;3:53-63.

Franklin-Ude PI, Emeje MO, Ofoefule SI. Evaluation of Gellan gum as

a mini-matrix for sustained release of ephedrine HCl granules. J of

Pharmacology and Toxicology 2007;2:646-52.

Carlfors J, Edsman K, Petersson R, Jornving K. Rheological evaluation of Gelrite in situ gels for ophthalmic use. Europ J Pharm Sci 1998;6:113-9.

Chilvers GR, Morris VJ. Coarcervation of gelatin-gellan gum mixtures and their use in micro encapsulation. Carbohy Dr. Polymer 1970;7: 111-20.

Kedzierewice F, Lombry C, Rios R, Hoffman M, Maincent P. Effect of the

formulation on the in vitro release of propranolol from gellan beads.

Int J Pharm 1999;178:129-36.

Korsemeyer RW, Gunny R, Doelker E, Buri P, Peppas NA. Mechanism

of solute release from porous hydrophilic polymers. Int J Pharm

;15:23-35.

Sood A, Panchangula R. Release evaluation of diltiazem CR preparations. Int J Pharm 1981;75:95-107.

Emeje MO, Kunle OO, Ofoefule SI. Effect of the Molecular size of

carboxymethylcellulose on the rates of hydration, matrix erosion and

drug release. Drug Deliv Technol 2005;5:86-91.