Floating bioadhesive drug delivery system using novel effervescent agents

Main Article Content

V S Belgamwar
S J Surana


Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from the upper gastrointestinal tract and improve the bioavailability of medications that are characterized by the narrow absorption
window. A new gastroretentive sustained release delivery system using the novel effervescent system was developed with floating, swellable, and bioadhesive properties. Various release retarding polymers like psyllium husk, HPMC K15M, and a swelling agent crosspovidone in different combinations were tried and optimized to get the release profile for 12 hours. The  formulations were evaluated for physicochemical characteristics, in vitro drug release profile, swelling characteristics, floating capacity, and in vitro bioadhesive property. in vitro drug release followed the Higuchi kinetics and the release mechanism was
found to be of a non-Fickian type. The swelling properties were increased with increasing crosspovidone concentration and contributed to the drug release from the tablet matrix. In this study, an attempt has been made to explore novel effervescent agents such as citroglycine and disodium glycine carbonate for achieving the desired floating time.


Download data is not yet available.

Article Details

How to Cite
Belgamwar, V. S., & Surana, S. J. (2014). Floating bioadhesive drug delivery system using novel effervescent agents. Asian Journal of Pharmaceutics (AJP), 3(2). https://doi.org/10.22377/ajp.v3i2.259


Singh BN, Kim KH. Floating drug delivery systems: An approach to

oral controlled drug delivery via gastric retention. J Control Release


Michaels AS. Drug delivery device with self actuated mechanism for

retaining device in selected area. 1979;US Patent 3:786-813.

Sheth PR, Tossounian J. The hydrodynamically balanced system (HBS):

A novel drug delivery system for oral use. Drug Development and

Industrial Pharmacy 1994;20:313-39.

Gennaro AR, Remington. The Science and Practice of Pharmacy.

th ed, Easton, PA: Mack Publishing Company; 1990. p. 900-1.

Melander A, Stenberg P, Liedholm H, Schersten B, WÃ¥hlin-Boll E.

Food- nduced reduction in bioavailability of atenolol. Eur J Clin

iPharmacol 1979;16:327-30.

Hoffman BB. Catecholamine, sympathomimetics drugs, and adrenergic

receptor antagonists. Goodman and Gilman’s The Pharmacological

Basis of Therapeutics.In: J.G. Hardman, L.E. Limbird, editors. 10th ed.

NY, New York: McGraw Hill; 2001.

Vaithiyalingam SR, Sastry SV, Dehon RH, Reddy IK, Khan MA. Long- ermt stability characterization of a controlled release gastrointestinal

therapeutic system coated with a cellulose acetate pseudolatex.

Pharmazie 2001;56:66-9.

Sastry SV, Reddy IK, Khan MA. Atenolol gastrointestinal therapeutic

system: Optimization of formulation variables using response surface

methodology. Journal of Controlled Release 1997;45:121-30.

.Fischer MH, Yu N, Gray GR, Ralph J, Anderson L, Marlett JA. The gel

forming polysaccharide of psyllium husk (Plantago ovata Forsk).

CarbohyDr. Res 2004;339:2009-17.

Shidhaye S, Kadam VJ, Desai A. Possible use of psyllium husk as a release retardant. Indian Journal of Pharmaceutical Sciences 2007;69:206-10.

Chavanpatil MD, Jain P, Chaudhary S, Shear P, Vavia PR. Novel sustainedrelease, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm 2006;316:86-92.

Lalla JK, Gurnancy RA. Polymers for mucosal delivery-swelling and

mucoadhesive evaluation. Indian Drug. 2002;39:270-6.

Chary RB, Rao YM. Formulation and evaluation of methocel K15 M

bioadhesive matrix tablet. Drug Dev and Ind Pharm 2000;26:901-6.

Gupta A, Garg S, Khar RP. Measurement of bioadhesive strength of

mucoadhesive buccal tablets: Design of in vitro assembly. Indian Drug