Enhancement of solubility and dissolution of glipizide by solid dispersion (kneading) technique
Main Article Content
Abstract
in aqueous media by solid dispersion (SDs) technique with Poloxamer (PXM) 188 and Poloxamer (PXM) 407 by using the kneading method.The GZ-PXM solid dispersion system was characterized by dDifferential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transform-infrared spectroscopy (FT-IR) and Scanning electron microscopy (SEM), and in vitro dissolution studies. No chemical interaction was found between GZ and PXM 188 or PXM 407. The results from DSC, XRD and SEM studies show that PXM 188 or PXM 407 inhibits the crystallization of GZ. The SDs prepared in this study were found to have better dissolution rates in comparisoncompared to intact GZ and physical mixture of PXM 188 or PXM 407 and GZ. It was found that the optimum weight ratio for drug: Carrier is 1:5 for PXM 188 and 1:6 for PXM 407.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Serajuddin AT. Solid dispersion of poorly water soluble drugs: Early
promises, subsequent problems and recent breakthrough. J Pharm Sci
;88:1058-66.
Lobenberg R, Amidon GL. Modern bioavailability bioequivalence and
biopharmaceutics classification system: New scientific approaches to
international regulatory standards. Eur J Pharm Biopharm 2000;50:3-12.
Sharma DK, Joshi SB. Solubility enhancement strategies for poorly
water soluble drugs in solid dispersion: A Review. Asian J Pharm
;1:9-19.
Pouton CW. Formulation of poorly water-soluble drugs for oral
administration: Physicochemical and physiological issues and the lipid
formulation classification systems. Eur J Pharm Sci 2006;29:278-87.
Leuner C, Dressman J. Improving drug solubility for oral delivery using
solid dispersion. Eur J Pharm Biopharm 2000;50:47-60.
Vasconceleos T, Sarmento B, Costa P. Solid dispersion as strategy to
improve oral bioavailability of poor water soluble drugs. Drug Discovery
Today 2007;12:1068-75.
Craig DQ. The mechanism of drug release from solid dispersions in
water-soluble polymers. Int J Pharm 2002;231:131-44.
Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion
systems. J Pharm Sci 1971;60:1281-302.
Aly AM, Qato MK, Ahmad MO. Enhancement of the dissolution rate
and bioavailability of glipizide through cyclodextrin inclusion complex.
Pharma Tech 2003;7:54-62.
Mehramizi A, Alijani B Pourfarzib M. Solid carriers for improved
solubility of glipizide in osmotically controlled oral drug delivery
system. Drug Dev Ind Pharm 2007;33:812-23.
Himasankar K, Babu GV, Babu PS, Prasad CD, Rao LN Murthy KV.
Studies on the solid dispersion systems of glipizide. Indian J Pharm
Sci 2002;64:433-9.
Modi A, Tayade P. Enhancement of dissolution profile by solid dispersion
(kneading) technique. AAPS PharmsciTech 2006;7:68.
Kalaiselvan R, Mohanta GP, Manna PK, Manavalan R. Studies on
machenism of enhanced dissolution of albendazole solid dispersion
with crystalline carriers. Indian J Pharm Sci 2006;68:599-607.
Rao MV, Shyam T, Appa RB, Srinivasa RY. Formulation and characterization
of meloxicam solid dispersions. The Indian Pharmacist 2008;70:67-70.
Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem
Instr 1965;4:117-212.
Khan KA. The concept of dissolution efficiency. J Pharm Phamacol
;27:48-9.