Nanoparticles based on PLGA and its coâ€polymer: An overview
Main Article Content
Abstract
PLGA and its co-polymer are important in designing nanoparticles with desired characteristics such as biocompatibility, biodegradation, particle size, surface properties, drug release and targetability.This review focuses on the polymer literature, methods for preparation of nanoparticles and recent studies on the nanoparticles based on PLGA and its co-polymer for the
conventional and targeted delivery of drugs by various routes.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Allemann E, Gurny R, Doelker E. Drug-loaded nanoparticles-prepa
ration methods and drug targeting issues. Eur J Pharm Biopharm
;39:173â€91.
Muthu MS, Singh S. Targeted nanomedicines: Effective treatment
modalities for cancer, AIDS and brain disorders. Nanomed 2009;4:105â€18.
Labhasetwar V, Song C, Levy RJ. Nanoparticles drug delivery systems.
Adv Drug Deliv Rev 1997;24:63-85.
Stevanović M, Savić J, Jordović B, Uskoković D. Fabrication, in vitro
degradation and the release behaviours of poly(DL-lactide-co-glycolide)
nanospheres containing ascorbic acid. Colloids Surf B Biointerfaces
;59:215-23.
Pinto Reis C, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation I.
Methods for preparation of drug-loaded polymeric nanoparticles.
Nanomedicine 2006;2:8-21.
Verger ML, Fluckiger L, Kim Y, Hoffman M, Maincent P. Preparation and
characterization of nanoparticles containing an antihypertensive agent.
Eur J Pharm Biopharm 1998;46:137-43.
Mainardes RM, Evangelista RC. PLGA nanoparticles containing
praziquantel: Effect of formulation variables on size distribution. Int J
Pharm 2005;290:137-44.
Hans ML, Lowman AM. Biodegradable nanoparticles for drug delivery
and targeting. Curr Opin Sol State Mater Sci 2002;6:319-27.
Zhao Y, Chen W, Cai Q, Wang S, Bo J, Wu C. Erosion induced controllable
release of gliclazide encapsulated inside degradable polymeric
particles. Macromol Biosci 2004;4:308-13.
Lewis DD. Controlled release of bioactive agents from lactide/glycolide
polyiners. In: Chasin M, Langer R, eds. Biodegradable Polymers as Drug
Delivery Systems. New York, Marcel Dekker; 1990. p. 1-41.
Gilding DK, Reed AM. Biodegradable polymers for use in surgery.
Polyglycolic/poly(lactic acid) homo- and copolymers: 1. Polymer
;20:1459-64.
Athanasiou KA, Niederauer GG, Agrawal CM. Sterilization, toxicity,
biocompatibility and clinical applications of polylactic acid/polyglycolic
acid copolymers. Biomaterials 1996;17:93-102.
Ravivarapu HB, Burton K, DeLuca PP. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur J Pharm Biopharm 2000;50:263-70.
Li S, McCarthy SP. Influence of crystallinity and stereochemistry
on the enzymatic degradation of poly(lactide)s. Macromolecules
;32:4454-56.
Schliecker G, Schmidt C, Fuchs S, Kissel T. Characterization of a
homologous series of D,L-lactic acid oligomers; a mechanistic study
on the degradation kinetics in vitro. Biomaterials 2003;24:3835-44.
Park TG. Degradation of poly(D,L-lactic acid) microspheres: Effect of
molecular weight. J Control Release 1994;30:161-73.
Vert M. Aliphatic polyesters: Great degradable polymers that cannot
do everything. Biomacromolecules 2005;6:538-46.
Makino K, Arakawa M, Kondo T. Preparation and in vitro degradation
properties of polylactide microcapsules. Chem Pharm Bull 1985;33:
-1201.
Göpferich A. Mechanisms of polymer degradation and erosion.
Biomaterials 1996;42:1-11.
Visscher GE, Pearson JE, Fong JW, Argentieri GJ, Robison RL, Maulding
HV. Effect of particle size on the in vitro and in vivo degradation rates
of poly(DL-lactide-co-glycolide) microcapsules. J Biomed Mater Res
;22:733-46.
Anderson JM. In vivo biocompatibility of implantation delivery systems
and biomaterials. Eur J Pharm Biopharm 1994;40:1-8.
Visscher GE, Robison RL, Maulding HV, Fong JW, Pearson JE, Argentieri GJ.
Biodegradation of and tissue reaction to 50:50 poly(DL-lactide-co-
glycolide) microcapsules. J Biomed Mater Res 1985;19:349â€65.
Visscher GE, Robison RL, Maulding HV, Fong JW, Pearson JE,
Argentieri GJ. Biodegradation of and tissue reaction to poly(DL-lactide)
microcapsules. J Biomed Mater Res 1986;20:667-76.
Ziats NP, Miller KM, Anderson JM. In vivo and in vitro interaction of cells
with biomaterials. Biomaterials 1988;9:5-3.
Ward PA. Recruitment of inflammatory cells into lung: Roles of
cytokines, adhesion molecules, and complement. J Lab Clin Med
;129:400-04.
Comets E, Mentré F, Kawai R, Nimmerfall F, Marbach P, Vonderscher J.
Modeling the kinetics of release of octreotide from long-acting
formulations injected intramuscularly in rabbits. J Pharm Sci
;89:1123-33.
Julienne MC, Alonso MJ, Gomez Amoza JL, Benoit JP. Preparation of
poly(DL-lactide/glycolide) nanoparticles of controlled particle size
distribution: Application of experimental designs. Drug Dev Ind Pharm
;18:1063-77.
Yoo HS, Oh JE, Lee KH, Park TG. Biodegradable nanoparticles
containing doxorubicin-PLGA conjugate for sustained release. Pharm
Res 1999;16:1114-18.
Allémann E, Leroux JC, Gurny R, Doelker E. In vitro extended-release
properties of drug-loaded poly(DL-lactic acid) nanoparticles produced
by a salting-out procedure. Pharm Res 1993;10:1732-37.
Fessi H, Puisieux F, Devissaguet JP. Process for the preparation of
dispersible colloidal systems of a substance in the form of nanoparticles.
United States Patent 1992;5:118-528.
Jung T, Breitenbach A, Kissel T. Sulfobutylated poly(vinyl alcohol)-graft-
poly(lactide-co-glycolide)s facilitate the preparation of small negatively
charged biodegradable nanospheres. J Control Release 2000;67:157-69.
Dreis S, Rothweiler F, Michaelis M, Cinatl J Jr, Kreuter J, Langer K.
Preparation, characterisation and maintenance of drug efficacy of
doxorubicin-loaded human serum albumin (HSA) nanoparticles. Int J
Pharm 2007;341:207-14.
Piñón-Segundo E, Ganem-Quintanar A, Alonso-Pérez V, Quintanarâ€
Guerrero D. Preparation and characterization of triclosan nanoparticles
for periodontal treatment. Int J Pharm 2005;294:217-32.
Dong Y, Feng SS. Poly(d,l-lactide-co-glycolide)/montmorillonite
nanoparticles for oral delivery of anticancer drugs. Biomaterials
;26:6068-76.
Bala I, Bhardwaj V, Hariharan S, Kharade SV, Roy N, Ravi Kumar MN.
Sustained release nanoparticulate formulation containing antioxidant-
ellagic acid as potential prophylaxis system for oral administration.
J Drug Target 2006;14:27-34.
Pandey R, Khuller GK. Nanoparticle-based oral drug delivery system
for an injectable antibiotic - streptomycin. Evaluation in a murine
tuberculosis model. Chemotherapy 2007;53:437-41.
Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MN. Estradiol loaded
PLGA nanoparticles for oral administration: Effect of polymer molecular
weight and copolymer composition on release behavior in vitro and
in vivo. J Control Release 2007;119:77-85.
Italia JL, Bhatt DK, Bhardwaj V, Tikoo K, Kumar MN. PLGA nanoparticles
for oral delivery of cyclosporine: Nephrotoxicity and pharmacokinetic
studies in comparison to Sandimmune Neoral. J Control Release
;119:197-206.
Lecaroz MC, Blanco-Prieto MJ, Campanero MA, Salman H, Gamazo C.
Poly(D,L-lactide-coglycolide) particles containing gentamicin:
Pharmacokinetics and pharmacodynamics in Brucella melitensis-
infected mice. Antimicrob Agents Chemotherr 2007;51:1185-90.
Muthu MS, Rawat MK, Mishra A, Singh S. PLGA nanoparticle
formulations of risperidone: Preparation and neuropharmacological
evaluation. Nanomedicine 2009;5:323-33.
Davaran S, Rashidi MR, Pourabbas B, Dadashzadeh M, Haghshenas
NM. Adriamycin release from poly(lactide-coglycolide)-polyethylene
glycol nanoparticles: Synthesis, and in vitro characterization. Int J
Nanomedicine 2006;1:535-9.
Choi SW, Kim JH. Design of surface-modified poly(D,L-lactide-co-
glycolide) nanoparticles for targeted drug delivery to bone. J Control
Release 2007;122:24-30.
Mattheolabakis G, Taoufik E, Haralambous S, Roberts ML, Avgoustakis K.
In vivo investigation of tolerance and antitumor activity of cisplatin-
loaded PLGA-mPEG nanoparticles. Eur J Pharm Biopharm 2007;71:190â€95.
Duguet E, Vasseur S, Mornet S, Devoisselle JM. Magnetic nanoparticles
and their applications in medicine. Nanomed 2006;1:157-68.
Ngaboni Okassa L, Marchais H, Douziech-Eyrolles L, Cohen-Jonathan S,
Soucé M, Dubois P, et al. Development and characterization of
subâ€micron poly(D,L-lactide-co-glycolide) particles loaded with
magnetite/maghemite nanoparticles. Int J Pharm 2005;302:187-96.
Jones M, Leroux J. Polymeric micelles - a new generation of colloidal
drug carriers. Eur J Pharm Biopharm 1999;48:101-11.
Yoo HS, Park TG. Biodegradable polymeric micelles composed of
doxorubicin conjugated PLGA-PEG block copolymer. J Control Release
;70:63-70.