Using Inverted Microemulsions for Transdermal Application of Folic Acid
Main Article Content
Abstract
Objectives: This study aimed to improve and assess the transdermal of folic acid through the skin through
non-ionic microemulsions (MEs). Methods and Instruments: Eight MEs were developed with different ratios
of Span 20-to-Tween 80 and folic acid contents. These MEs were characterized for their droplet sizes, rheological
properties. Besides, the encapsulation of folic acid insides the MEs was studied using Fourier-transform infrared
spectroscopy. Furthermore, the flux of formulated folic acid in MEs was evaluated using Franz diffusion cell.
Results: The MEs showed Newtonian viscosity and droplets sizes <200 nm. However, the droplets sizes
increased with increasing Tween 80 and folic acid content. Furthermore, the flux of folic acid related to folic
acid concentration. However, using MEs, a high flux of 11.47 ± 6.9 × 10−4 μg/cm2 × h of folic acid through rat’s
skin could be achieved. Conclusion: The developed non-ionic MEs containing folic acid can be ideal carriers for
administration of folic acid transdermally.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.