Preparation and optimization of sustained release matrix tablets of metoprolol succinate and taro gum using response surface methodology
Main Article Content
Abstract
as the model drug. 32 full optimization procedure was adopted where two factors are studied at three levels. The amount
of taro gum (X1) and polyvinylpyrrolidone (PVP) K30 (X2) were selected as independent variables. The time required
for 90% of drug release was selected as the dependent variable. Tablets were prepared by direct compression and were
evaluated for various post compression parameters such as tablet hardness, friability, weight variation, drug content and
in vitro dissolution. The results were found to be within the acceptable limits. The release exponent (n) lies between 0.416
and 0.584 indicating drug release from the matrix tablets may be fickian or non‑fickian (anomalous) depending upon the
concentration of natural polymer. T90 was 10.70, 11.20, 12.05, 12.66 h for B6, B7, B8 and B9 batches respectively showing
overriding potential of taro gum, but still the effect of PVP K 30 is noteworthy. PVP K 30 has an indirect effect on all the
factors by increasing tensile strength and making the tablet firm and intact.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Singh B, Kumar R, Ahuja N. Optimizing drug delivery systems using systematic “design of experimentsâ€. Part I: Fundamental aspects. Crit Rev Ther Drug Carrier Syst 2005;22:27‑105.
Singh B, Dahiya M, Saharan V, Ahuja N. Optimizing drug delivery
systems using system-atic “design of experimentsâ€. Part II: Retrospect
and prospects. Crit Rev Ther Drug Carrier Syst 2005;22:215‑93.
“Metoprololâ€. The American Society of Health‑System Pharmacists.
Retrieved 3 April 2011.
Lin H, Huang AS. Chemical composition and some physical
properties of a water‑soluble gum in taro (Colocasia esculenta). Food
Chemistry.1993;48:403‑9.
Chukwu KI, Udeala OK. Binding effectiveness of Colocasia esculenta
gum in poorly com-pressible drugs‑paracetamol and metronidazole
tablet formulations. Boll Chim Farm 2000;139:89‑97.
Anthony Armstrong N. Factorial Design of Experiments. In: N. Anthony
Armstrong. Editors. Pharmaceutical Experimental Design and
Interpretation. 2nd ed. Taylor and Francis group, New York: 2006, Pg. 83-134.
Patel YL, Sher P, Pawar AP. The Effect of Drug Concentration And
Curing Time On Processing And Properties of Calcium Alginate Beads
Containing Metronidazole by Response Surface Methodology. AAPS
Pharm Sci Tech 2006;7:Article-86.
Kuchekar BS, Badhan AC. Mouth dissolving tablets of salbutamol
sulphate; a novel drug delivery system Ind Drugs, 2004;41:592‑7.
Shanmungam S, Cendilkumar A. rapidly disintegrating oral tablets of
valdecoxib. Ind Drugs 2005;42:685‑8.
Mishra DN. Rapidly disintegrating oral tablets of meloxicam by direct
compression method Ind. Drugs 2006;43:117‑2.
Raghavendra Rao NG, Ravi Kumar K, Setty CM, Purushotham Rao K,
‘Formulation And Evaluation Of Fast Dissolving Chlorthalidone Tablets’,
International Journal of Pharmacy and Pharmaceutical Sciences 2009;1
Suppl 1:79-87.
Brahmankar DM, Jaiswal SB. Controlled Release Medication. In:
Brahmankar DM. Editors. A Textbook of Biopharmaceutics and
pharmacokinetics A Treatise. 1st Ed.Vallabh prakashan. New Delhi: 1995,
p. 64‑70.
Higuchi T. Rate of release of medicament from ointment bases
containing drugs in suspension. J Pharm Sci 1961;50:874‑5.
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms
of solute release from porous hydrophilic polymers. Int J Pharm
;15:25-35.
Peppas NA. Analysis of Fickian and non‑Fickian drug release from
polymers. Pharm Acta Helv 1985;60:110‑11.
Hixson AW, Crowell JH. Dependence of reaction velocity upon
surface and agitation (I) theoretical consideration. Ind Eng Chem
;23:923-93122.