Topical non steroidal anti inflammatory drug (NSAIDs) microemulsions: Rationale, review and future prospective

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Vinod Singh
Hitesh Sharma
Ram Veerma
Athar Javed
Mamta Singh


Microemulsions serve as ideal candidates as potential drug delivery system due to their specialized qualities of improved solubilisation of drug, extended shelf life and ease of method of preparation and administration to patients.The unique
features of microemulsions are thermodynamically stable, clear, colloidal dispersion of water and oil that are stabilized by surfactant and cosurfactant. Microemulsion typically has a droplet diameter of approximately 100 nm or less. Microemulsions
have numerous applications in pharmaceutics and many other industries. In the present review we shall discuss about the various aspects of microemulsion with respect to the field of non steroidal anti inflammatory drug, along with its preparation,evaluation and research work carried out in microemulsion.


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Singh, V., Sharma, H., Veerma, R., Javed, A., & Singh, M. (2014). Topical non steroidal anti inflammatory drug (NSAIDs) microemulsions: Rationale, review and future prospective. Asian Journal of Pharmaceutics (AJP), 7(1).


David AO, Anton HA. Topical Drug Delivery Formulations. New York:

Marcel Dekker; 1990. p. 1.

Hoar TP, Schulman JH. Transparent water in oil dispersions: The

oleopathic hydromicelle. Nat 1943;152:102â€3.

Attwood D, Kreuter J. Colloidal Drug Delivery System. New York: Marcel

Dekker; 1994. p. 31â€71.

Heyneman CA, Lawlessâ€Liday C, Wall GC. Oral versus topical NSAIDs in

rheumatic diseases: A comparison. Drugs 2000;60:555â€74.

Gupta RR, Jain SK, Varshney M. AOT waterâ€inâ€oil microemulsions as a

penetration enhancer in transdermal drug delivery of 5â€fluorouracil.

Colloids Surf B Biointerfaces 2005;41:25â€32.

Peltola S, Saarinenâ€Savolainen P, Kiesvaara J, Suhonen TM, Urtti A.

Microemulsions for topical delivery of estradiol. Int J Pharm


Changez M, Chander J, Dinda AK. Transdermal permeation of

tetracaine hydrochloride by lecithin microemulsion: In vivo. Colloids

Surf B Biointerfaces 2006;48:58â€66.

Chen H, Chang X, Weng T, Zhao X, Gao Z, Yang Y, et al., A study of

microemulsion systems for transdermal delivery of triptolide. J Control

Release 2004;98:427â€36.

Chen H, Chang X, Du D, Li J, Xu H, Yang X. Microemulsionâ€based

hydrogel formulation of ibuprofen for topical delivery. Int J Pharm


Singh V, Bushettii SS, AppalaRaju S, Ahmad R, Singh M, Bisht A.

Microemulsions as a promising delivery systems: A review. Ind J Pharm

Edu Res 2011;4:54.

von Corswant C, Thorén P, Engström S. Triglycerideâ€based

microemulsion for intravenous administration of sparingly soluble

substances. J Pharm Sci 1998;87:200â€8.

Aboofazeli R, Patel N, Thomas M, Lawrence MJ. Investigations into

the formation and characterization of phospholipids microemulsions.

iv. pseudo â€ternar y phase diagrams of systems containing

waterâ€lecithinâ€alcohol and oil; the influence of oil. Int J Pharm


Guy RH. Current status and future prospects of transdermal drug

delivery. Pharm Res 1996;13:1765â€9.

Gordon RD, Peterson TA. Four myths about transdermal drug delivery.

Drug Deliv Technol 2003;3:1â€7.

Boucaud A. Trends in the use of ultrasoundâ€mediated transdermal drug

delivery. Drug Discov Today 2004;9:827â€8.

Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 2004;3:115â€24.

Bagwe RP, Kanicky JR, Palla BJ, Patanjali PK, Shah DO. Improved drug

delivery using microemulsions: Rationale, recent progress, and new

horizons. Crit Rev Ther Drug Carrier Syst 2001;18:77â€140.

Fang JY, Lin HH, Hsu LR, Tsai YH. Characterization and stability of

various liposomeâ€encapsulated enoxacin formulations. Chem Pharm

Bull (Tokyo) 1997;45:1504â€9.

Gutati M, Grover M, Singh S, Singh M. Lipophilic drug derivatives in

liposomes. Int J Pharm 1998;165:129â€68.

Martin A. Coarse dispersions. In: Physical Pharmacy. 4th ed. New Delhi:B.I. Waverly Pvt, Ltd; 1994. p. 495â€6.

Shah DO, Hamlin RM Jr. Structure of water in microemulsions: Electrical,birefringence, and nuclear magnetic resonance studies. Science


Shinoda K, Freiberg S. Microemulsions: Colloidal aspects. Adv Colloid

Interface Sci 1975;4:281â€300.

Tenjarla S. Microemulsions: An overview and pharmaceutical

applications. Crit Rev Ther Drug Carrier Syst 1999;16:461â€521.

Attwood D, Mallon C, Taylor CJ. Phase studies of oilâ€in water

phospoholipid microemulsions. Int J Pharm 1992;84:45â€8.

Ghosh PK, Murthy RS. Microemulsions: A potential drug delivery system.Curr Drug Deliv 2006;3:167â€80.

Lawrence MJ, Rees GD. Microemulsionâ€based media as novel drug

delivery systems. Adv Drug Deliv Rev 2000;45:89â€121.

Stilbs P, Lindman B, Rapacki k. Effect of alcohol cosurfactant length on

microemulsion structure. J Colloid Interface Sci 1983;95:583â€5.

Mitra N, Mukherjee L, Bhattacharya PK, Moulik SP. Biological

microemulsions V: Mutual mixing of oils, amphiphiles and water

in ternary and quaternary combinations. Indian J Biochem Biophys


Jadhav KR, Shetye SL, Kadam VJ. Design and evaluation of microemulsions

based drug delivery system. Int J Adv Pharm Sci 2010;1:156â€66.

Kreilgaard M, Pedersen EJ, Jaroszewski JW. NMR characterisation

and transdermal drug delivery potential of microemulsion systems.

J Control Release 2000;69:421â€33.

Malcolmson C, Lawrence MJ. A comparison between nonâ€ionic micelles

and microemulsions as a means of incorporating the poorly water

soluble drug diazepam. J Pharm Pharmacol 1990;42:6.

Malcolmson C, Satra C, Kantaria S, Sidhu A, Lawrence MJ. Effect of oil

on the level of solubilization of testosterone propionate into nonionic

oilâ€inâ€water microemulsions. J Pharm Sci 1998;87:109â€16.

Malcolmson C, Lawrence MJ. A comparison of the incorporation of

model steroids into nonâ€ionic micellar and microemulsion systems.

J Pharm Pharmacol 1993;45:141â€3.

Shinoda K, Kunieda H. Conditions to produce so-called microemulsions:

Factors to increase the mutual solubility of oil and water by solubilizer.

J Colloid Interface Sci 1973;42:381.

Shafiqâ€unâ€Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A,

et al., Formulation development and optimization using nanoemulsion

technique: A technical note. AAPS Pharm Sci Tech 2007;8:Article 28 .

Talegaonkar S, Azeem A, Ahmad FJ, Khar RK, Pathan SA, Khan ZI.

Microemulsions: A novel approach to enhanced drug delivery. Recent

Pat Drug Deliv Formul 2008;2:238â€57.

Rosano HL. Microemulsions and method for preparing microemulsion.

J Colloid Interface Sci 1973;44:242.

Pawar AY. Formulation, development and evaluation of topical

microemulsion gels for nimsulide. J Pharm Res 2011;4:1004â€6.

Kalra R, Mulik RS, Badgujar L, Paradkar AR, Mahadik KR, Bodhankar SL,

Sharma S. Development and characterization of microemulsion

formulation for transdermal delivery of acelofenac: A research. Int J

Drug Formul Res 2010;1:359â€86.

Gohel MC, Nagori SA. Fabrication and evaluation of hydrogel thickened

microemulsion of ibuprofen for topical delivery. Indian J Pharm Educ

Res 2010;44:189â€96.

Sakeena MH, Muthanna FA, Ghassan ZA, Kanakal MM, Elrashid SM,

Munavvar AS, et al., Formulation and in vitro evaluation of ketoprofen

in palm oil esters nanoemulsion for topical delivery. J Oleo Sci


Dhamankar AK, Manwar JV, Kumbhar DD. The novel formulation

design of o/w microemulsion of ketoprofen for improving transdermal

absorption. Int J Pharm Tech Res 2009;1:1449â€57.

Dima S, Popescu M. Topical delivery of diclofenac using microemulsion

systems. Rom Biotechnol Lett 2008;13:49â€55.

Zabka M, Skoviera F. Microemulsion as vehicle for transdermal

permeation of drugs. Acta Facult Pharm Univ Comenianae


Andrade SM, Costa SM. Fluorescence quenching of Acridine Orange in

microemulsions induced by the nonâ€steroidal antiâ€inflammatory drug

Piroxicam. Photochem Photobiol Sci 2003;2:605â€10.

Paolino D, Ventura CA, Nisticò S, Puglisi G, Fresta M. Lecithin

microemulsions for the topical administration of ketoprofen:

Percutaneous adsorption through human skin and in vivo human skin

tolerability. Int J Pharm 2002;244:21â€31.

Rhee YS, Choi JG, Park ES, Chi SC. Transdermal delivery of ketoprofen

using microemulsions. Int J Pharm 2001;228:161â€70.

Dalmora ME, Dalmora SL, Oliveira AG. Inclusion complex of piroxicam

with betaâ€cyclodextrin and incorporation in cationic microemulsion.

In vitro drug release and in vivo topical antiâ€inflammatory effect. Int J

Pharm 2001;222:45â€55.

Trotta M. Influence of phase transformation on indomethacin release

from microemulsions. J Control Release 1999;60:399â€405.49.