Development and evaluation of xyloglucan matrix tablets containing naproxen

R V Kulkarni, Anirudh Shah, Rashmi Boppana

Abstract


The xyloglucan (XGL) matrix tablets containing naproxen were prepared by conventional wet granulation technique
and evaluated for its drug release characteristics. Hardness of the tablets was found to be in the range of 5.0-7.0 kg/
cm2. The tablets showed 98.23-99.12% of the labeled amount of drug, indicating uniformity in drug content. The swelling
index increased with the increase in concentration of XGL and with the addition of hydroxypropylmethyl cellulose (HPMC)
in the matrices, whereas swelling index decreased with the addition of cellulose acetate phthalate (CAP) and ethyl cellulose
(EC). The compaction pressure had no significant effect on the drug release. Increase in polymer content and increased
initial drug loading resulted in decreased drug release from the tablets. Addition of HPMC, CAP, and EC to XGL tablets
decreased the drug release, and release was extended over a period of 8 h. The mechanism of release from all the tablets
deviated from Fickian mode.
Key words: Drug release, matrix tablets, naproxen, xyloglucan

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DOI: http://dx.doi.org/10.22377/ajp.v2i2.331

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