Main Article Content
and evaluated for its drug release characteristics. Hardness of the tablets was found to be in the range of 5.0-7.0 kg/
cm2. The tablets showed 98.23-99.12% of the labeled amount of drug, indicating uniformity in drug content. The swelling
index increased with the increase in concentration of XGL and with the addition of hydroxypropylmethyl cellulose (HPMC)
in the matrices, whereas swelling index decreased with the addition of cellulose acetate phthalate (CAP) and ethyl cellulose
(EC). The compaction pressure had no significant effect on the drug release. Increase in polymer content and increased
initial drug loading resulted in decreased drug release from the tablets. Addition of HPMC, CAP, and EC to XGL tablets
decreased the drug release, and release was extended over a period of 8 h. The mechanism of release from all the tablets
deviated from Fickian mode.
Key words: Drug release, matrix tablets, naproxen, xyloglucan
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. Drug
diffusion front movement is important in drug release control from
swellable matrix tablets. J Pharm Sci 1995;84:991-7.
Vazquez MJ, Perez-Marcos B, Gomez-Amoza JL, Martines, Pacheco R,
Souto C, et al. Influence of technological variables on release of drugs
from hydrophilic matrices. Drug Dev Ind Pharm 1992;18:1355-75.
Bonferoni MC, Rossi S, Tamayo M, Pedraz JL, Dominguez Gil A,
Caramella C. On the employment of l-Carrageenan in a matrix
system I. Sensitivity to dissolution medium and comparison with
Na carboxymethyl cellulose and Xanthan gum. J Control Release
Ford JL, Ribinstein MH, McCaul F, Hogan JE, Edgar PJ. Importance of drug
type, tablet shape and added diluents on drug release kinetics from
hydroxypropyl methyl cellulose matrix tablets. Int J Pharm 1987;40:
Talukdar MM, Plaizier-Vercammen J. Evaluation of xanthan gum as a
hydrophilic matrix for controlled release dosage form preparations.
Drug Dev Ind Pharm 1993;19:1037-46.
Risk S, Duru D, Gaudy D, Jacob M. Natural polymer hydrophilic matrix:
influencing drug release factors. Drug Dev Ind Pharm 1994;20:2563-74.
Sujja-areevath J, Munday DL, Cox PJ, Khan KA. Release characteristics
of diclofenac sodium from encapsulated natural gum mini-matrix
formulations. Int J Pharm 1996;139:53-62.
Khullar P, Khar RK, Agarwal SP. Evaluation of guar gum in the preparation
of sustained-release matrix tablets. Drug Dev Ind Pharm 1998;24:
Rao PS, Ghosh TP, Krishna S. Extraction and purification of tamarind
seed polysaccharide. J Sci Ind Res 1946;4:705.
Sano M, Miyata E, Tamano S, Hagiwara A, Ito N, Shirai T. Lack of
carcinogenicity of tamarind seed polysaccharide in B6C3F mice. Food
Chem Toxicol 1996;34:463-7.
Burgalassi S, Panichi L, Saettone MF, Jacobsen J, Rassing MR. Development
and in vitro/in vivo testing of mucoadhesive buccal patches releasing
benzydamine and lidocaine. Int J Pharm 1996;133:1-7.
Rao PS, Srivastava HC. Tamarind in industrial gums. In: Whistler RL,
editor. 2nd ed, New York: Academic Press; 1973. p. 369-411.
Meier H, Reid JS. Reserve polysaccharides other than starch in higher
plants in Encyclopedia of plant physiology, NS: Plant Carbohydrates I:
Intracellular carbohydrates. In: Loewus FA, Tanner W, editors. Vol. 134,
Springer- Verlag; 1982. p. 418-71.
Gerard T. Tamarind Gum In Handbook of water-soluble gums and
resins. In: Davidson RL, editor. USA: McGraw-Hill Book Co; 1980.
Gidley MJ, Lillford PJ, Rowlands DW. Structural and solution properties of
tamarind-seed polysaccharide. Carbohydrate Res 1991;214:299-314.