Effect of Surfactant Concentration on the Entrapment Efficiency Niosomes Aqueous Extract of Cassava Leaves (Manihot esculenta Crantz)

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Hilmy Nur Hichmah

Abstract

Context: Aqueous extract of cassava leaves (Manihot esculenta Crantz) has a high rutin content. Rutin has
benefits as an antioxidant, anti-inflammatory, analgesic, and antidiabetic. The plant extract has low bioavailability
and has a large molecular weight. Therefore, a carrier system like niosomes is required to allow aqueous leaves
extract of cassava through to absorb in the body. Aims: The purpose of this study was to determine the effect
of variation concentration of Span 40 that can trap aqueous extract of cassava leaves in niosomes optimally.
Materials and Methods: Niosomes were done by thin-layer hydration method with concentration of Span 40
which was varied into three formulas: Formula A (100 μmol), Formula B (150 μmol), and Formula C (200 μmol).
Statistical Analysis Used: The data analysis using SPSS analyzed by one-way ANOVA. Results: The rutin
contained in cassava leaves of this research is 42.52%. Entrapment efficiency test used dialysis membrane method
and the result showed that the increased concentration of Span 40 is used; the entrapment efficiency is also
increasing. The result of SPSS test using one-way ANOVA of three formulas did not show significant difference
(P > 0.05). Conclusions: Optimum concentration of Span 40 in trapping aqueous extract of cassava leaves is
Formula A (100 μmol) which was 95.9%.

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How to Cite
Hichmah, H. N. (2019). Effect of Surfactant Concentration on the Entrapment Efficiency Niosomes Aqueous Extract of Cassava Leaves (Manihot esculenta Crantz). Asian Journal of Pharmaceutics (AJP), 13(04). https://doi.org/10.22377/ajp.v13i04.3397
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ORIGINAL ARTICLES