Floating bioadhesive matrix tablets of ondansetron HCl: Optimization of hydrophilic polymer‑blends

Main Article Content

Jadupati Malakar
Amit Kumar Nayak

Abstract

The work investigates the development and optimization of floating bioadhesive matrix tablets of ondansetron HCl for
gastroretentive delivery using 23 factorial design. The effects of xanthan gum, guar gum, carbopol 934 P as hydrophilic
polymer‑blends on drug release were analyzed. The optimized tablets were floated well in simulated gastric fluid (SGF)
(>8 h) with no lag‑time and also showed a good bioadhesion time (5.23 ± 0.25 min) on goat intestinal mucosa in SGF.
The in vitro drug release of these tablets showed sustained ondansetron HCl release over 8 h, which correlated well with
controlled‑release (zero order) pattern with super case‑II transport mechanism.
Key words: Bioadhesion, floatation, gastroretention, matrix tablets, ondansetron HCl, polymer‑blend

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How to Cite
Malakar, J., & Nayak, A. K. (2014). Floating bioadhesive matrix tablets of ondansetron HCl: Optimization of hydrophilic polymer‑blends. Asian Journal of Pharmaceutics (AJP), 7(4). https://doi.org/10.22377/ajp.v7i4.341
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References

Malakar J, Nayak AK, Goswami S. Use of response surface methodology

in the formulation and optimization of bisoprolol fumarate matrix

tablets for sustained drug release. ISRN Pharm 2012;2012:730624.

Ãœner M, Celebi B. Design of hydralazine hydrochloride matrix tablets

based on various polymers and lipids. Indian J Pharm Educ Res

;46:75‑87.

Abdel‑Rahman SI, Mahrous GM, El‑Badry M. Preparation and comparative

evaluation of sustained release metoclopramide hydrochloride matrix

tablets. Saudi Pharm J 2009;17:283‑8.

Gohel MC, Parikh RK, Nagori SA, Jena DG. Fabrication of modified

release tablet formulation of metoprolol succinate using hydroxypropyl

methylcellulose and xanthan gum. AAPS Pharm Sci Tech 2009;10:62‑8.

Joshi NC, Ahamad Z, Mishra SK, Sing R. Formulation and evaluation

of matrix tablet of tramadol hydrochloride. Indian J Pharm Educ Res

;45:360‑3.

Islam MS, Azam KR, Chowdhury JA, Reza MS. Comparision of gastro

retention time and in vitro release profile studies of ciprofloxacin HCl

from co‑matrix tablets of hydrophilic polymers. Dhaka Univ J Pharm

Sci 2009;8:67‑73.

Nayak AK, Maji R, Das B. Gastroretentive drug delivery systems:

A review. Asian J Pharm Clin Res 2010;3:2‑10.

Nayak AK, Malakar J, Sen KK. Gastroretentive drug delivery

technologies: Current approaches and future potential. J Pharm Educ

Res 2010;1:1‑12.

Nayak AK, Das B, Maji R. Gastroretentive hydrodynamically balanced

systems of ofloxacin: In vitro evaluation. Saudi Pharm J 2013;21:113‑7.

Guru PR, Nayak AK, Sahu RK. Oil‑entrapped sterculia gum‑alginate

buoyant systems of aceclofenac: Development and in vitro evaluation.

Colloids Surf B Biointerfaces 2013;104:268‑75.

Nayak AK, Malakar J. Formulation and in vitro evaluation of

hydrodynamically balanced system for theophylline delivery. J Basic

Clin Pharm 2011;2:133‑7.

Malakar J, Nayak AK, Pal D. Development of cloxacillin loaded

multiple‑unit alginate‑based floating system by emulsion‑gelation

method. Int J Biol Macromol 2012;50:138‑47.

Nayak AK, Hasnain MS, Beg S, Alam MI. Mucoadhesive beads of gliclazide:

Design, development and evaluation. Sci Asia 2010;36:319‑25.

Nayak AK, Pal D, Pradhan J, Hasnain MS. Fenugreek seed mucilage‑alginate

mucoadhesive beads of metformin HCl: Design, optimization and

evaluation. Int J Biol Macromol 2013;54:144‑54.

Nayak AK, Pal D. Ionotropically‑gelled mucoadhesive beads for oral

metformin HCl delivery: Formulation, optimization and antidiabetic

evaluation. J Sci Ind Res 2013;72:15‑22.

Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavia PR. Novel sustained

release, swellable and bioadhesive gastroretentive drug delivery system

for ofloxacin. Int J Pharm 2006;316:86‑92.

Belgamwar VS, Surana SJ. Floating bioadhesive drug delivery system

using novel effervescent agents. Asian J Pharm 2009;3:156‑60.

Chueh HR, Zin H, Rhodes CT. Optimization of sotalol floating and

bioadhesive extended release tablet formulations. Drug Dev Ind Pharm

;21:1725‑47.

Rathi M, Medhekar R, Pwar A, Yewale C, Gudsoorkar V. Floating and

bioadhesive delivery system of metoprolol succinate: Formulation,

development and in vitro evaluation. Asia J Pharm 2012;6:227‑36.

Malakar J, Nayak AK, Basu A. Ondansetron HCl microemulsions for

transdermal delivery: Formulation and in vitro skin permeation. ISRN

Pharm 2012;2012:428396.

Khan S, Kataria P, Nakhat P, Yeole P. Taste masking of ondansetron

hydrochloride by polymer carrier system and formulation of

rapid‑disintegrating tablets. AAPS Pharm Sci Tech 2007;8:Article 46.

Hassan N, Khar RK, Ali M, Ali J. Development and evaluation of buccal

bioadhesive tablet of an anti‑emetic agent ondansetron. AAPS Pharm

Sci Tech 2009;10:1085‑92.

Salem II, Lopez JM, Gulam AC. Ondansetron hydrochloride. In:

Brittan HG, editor. Analytical Profiles of Drug Substances and Excipients.

San Diego, California, USA: Academic Press; 2001. p. 301‑39.

Moin A, Shivakumar HG. Formulation of sustained‑release diltiazem

matrix tablets using hydrophilic gum blends. Trop J Pharm Res

;9:283‑91.

Nayak AK, Pal D, Malakar J. Development, optimization and evaluation

of emulsion‑gelled floating beads using natural polysaccharide‑blend

for controlled drug release. Polym Eng Sci 2013;53:338‑50.

Nayak AK, Das B, Maji R. Calcium alginate/gum Arabic beads containing

glibenclamide: Development and in vitro characterization. Int J Biol

Macromol 2012;51:1070‑8.

Nayak AK, Pal D, Santra K. Plantago ovata F. mucilage‑alginate

mucoadhesive beads for controlled release of glibenclamide:

Development, optimization and in vitro‑in vivo evaluation. J Pharm 2013;

Article ID:151035.

Shah M, Pathak K. Development and statistical optimization of solid

lipid nanoparticles of simvastatin by using 2 (3) full‑factorial design.

AAPS Pharm Sci Tech 2010;11:489‑96.

Madgulkar A, Kadam S, Pokharkar V. Studies on formulation development

of mucoadhesive sustained release itraconazole tablet using response

surface methodology. AAPS Pharm Sci Tech 2008;9:998‑1005.

Lewis GA, Mathieu D, Phan‑Tan‑Luu R. Response surface methodology.

In: Pharmaceutical Experimental Design. New York: Marcel Dekker Inc.;

US Pharmacopoeia National Formulary, USP 23/NF 18. Rockville, MD:

United States Pharmacopoeia Convention Inc.; 2000.

Allen LV, Popovich NG, Ansel HC. Ansel’s Pharmaceutical Dosage Forms

and Drug Delivery Systems. 8th ed. Philadelphia: Lippincott Williams

and Wilkins; 2004.

Patel VF, Patel NM. Statistical evaluation of influence of xanthan gum

and guar gum blends on dipyridamole release from floating matrix

tablets. Drug Dev Ind Pharm 2007;33:327‑34.