In situ gelling systems of ofloxacin: Comparative performance of in vivo precorneal drainage and pharmacokinetic study
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Abstract
chitosan, (pHâ€sensitive polymer also acts as a permeation enhancer) was used in temperature and pHâ€triggered in situ gelling systems while gellan alone was used in ionâ€activated in situ gelling system. The formulation allows its easy instillation into the eye as a liquid (drops), forms transparent gel, and spreads over the corneal surface. At the formulation pH, transcorneal permeation profile of ofloxacin was comparable to that of in vitro release profile. In situ gelâ€forming ability of the developed systems significantly controls precorneal drainage as studied by gamma scintigraphy. Thus, increased residence time in the
eye would help to increase the ocular bioavailability.The formulation was also found to be nonirritant and well tolerable. Cmax of in situ gelling formulation was found to be 1.5 times higher than marketed eye drops solution at the similar Tmax of 1 h.
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