Manifold Molecular Signaling Targets of Tropolones in Multifarious Diseases

Abstract

Tropolones are strewed phytochemicals having scaffold contains seven-membered ring system belongs to
a family of Cupressaceae plants. Tropolone derivatives targeting multiple signaling transcription factors, cell
cycle regulatory components, proteins, growth factors, kinases, and cytokines also involved in inflammatory
mechanisms as well as involved in antioxidant, antimicrobial, anti-inflammatory, antithrombotic, and anticancer
activities. To identify the therapeutically potent pharmacophores from the natural components is the long-term
focus in pharmaceutical industry. Our preliminary findings on Hinokitiol (HIOL) showed binding potential in
mitogen-activated protein kinase and ABL proto-oncogene 1 by in silico docking method perhaps in apoptosis
of several cancers. This review aimed at gathering most of the available information to document the potential
efficacy of tropolones and its molecular mechanisms. Although natural products usually have fewer activities
compared with synthesized compounds, it will shed a light on studies aiming to discover new drugs from tropolone
derivatives for targeting multiple signaling mechanisms for various diseases.