Formulation and evaluation of floating matrix tablets of diltiazem hydrochloride

Vinay D Gaikwad, Vishal D Yadav, Prakash D Jadhav

Abstract


This study was performed to design floating tablets of diltiazem as a model drug for prolongation of gastric residence time. A simple visible spectrophotometric method was employed for the estimation of diltiazem at 236 nm and Beer’s
law is obeyed in the concentration range of 2-20 mg/ml. Preformulation studies were carried out to optimize the ratios required for various grades of HPMC-SCMC and HPMC- Carbopol P934. Total 10 formulations (five each) were prepared
using HPMC (K4M). The prepared floating tablets were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, buoyancy lag time, total floating time, water uptake (swelling index), and in vitro dissolution studies.
SEM and stability studies were carried out only for best release formulations (A1 and B1). Among the five formulations with HPMC K4M and A1-A4 showed drug release ranging from 99.89 to 77.52%. Similarly five formulations with HPMC
K4M and Carbopol P934 (B1-B4) showed drug release ranging from 97.9 to 80.35% in 0.1 N HCl dissolution medium.Formulations A1 and B1 gave maximum drug release upto 100% within 12 hrs. SEM for A1 and B1 formulations revealed
that surface was smooth upto 4 hrs after that swelling and porosity of tablet increased indicating the diffusion and erosion
mechanism of release.


Full Text:

PDF

References


Shivakumar HG, Vishakanta Gowda D, Pramod Kumar. Floating

controlled drug delivery systems for prolonged gastric residence: A

review. Indian J Pharm Educ 2004;38:172-9.

Moin A, Shivakumar HG. Formulation of sustained-release diltiazem

matrix tablets using hydrophilic gum blends. Tropical J Pharm Res

;9:283-91.

Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery

system: A Review. AASP PharmSciTech 2005;6:372-83.

Kiil S, Dam-Johansen K. Controlled drug delivery from swellable hydroxyl

propylmethylcellulose matrices: Model-based analysis of observed

radial front movements. J Control Release 2003:90:1-21.

Rahman Z, Ali M, Khar R. Design and evaluation of bilayer floating

tablets of Captopril. Acta Pharm 2006;56:49-57.

Narendra C, Srinath MS, Babu G. Optimization of bilayer floating tablet

containing metoprolol tartarate as a model drug for gastric retention.

AAPS PharmSciTech 2006;7:E34.

Chavanpatil M, Jain P, Chaudhari S, Shear R, Vavia P. Development of sustained release gastroretentive drug delivery system for ofloxacin:

In vitro and in vivo evaluation. Int J Pharm 2005;304:178-84.

Bose SCP, Reddy SP, Valluru R, Saritha D, Kumar PTM. Formulation and evaluation of sustained release of floating tablets of diltiazem HCl using xanthan gum. Res J Pharm, Bio and Chem Sci 2011;2:319-28.

Xu X, Sun M, Zhi F, Hu Y. Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: In vitro and in vivo evaluation in healthy volunteers. Int J Pharm 2006;310:139-45.

Patel SS, Ray S, Thakur RS. Formulation and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. Acta

Pol Pharm 2006;63:53-61.

Sonar GS, Jain DK, More DM. Preparation and in vitro evaluation of

bilayer and floating-bioadhesive tablets of rosiglitazone maleate. Asian

J Pharm Sci 2007;2:161-9.

Stops F, Fell JT, Collett JH, Martini LG. Floating dosage forms to prolong

gastro-retention-The characterisation of calcium alginate beads. Int J

Pharm 2008;350:301-11.

Garg R, Gupta G D. Progress in controlled gastroretentive delivery

systems. Tropical J Pharmaceutical Res 2008;7:1055-66.

Basak SC, Rahman J, Ramalingam M. Desing and in vitro testing of a

floatable gastroretentive tablet of metformin hydrochloride. Pharmazie

;62:145-8.

Patel VF, Patel NM. Intragastric floating drug delivery system

of cefuroxime axetil: In vitro evaluation. AAPS PharmaSciTech

;7E17.

Gupta Shishu N, Aggarwal N. A gastro-retentive floating delivery system for 5-fl uorouracil. Asian J Pharm Sci 2007;2:143-9.

Bhise SB, Aloorkar NH. Formulation and in vitro evaluation of floating

capsules of theophylene. Indian J Pharm Sci 2008;70:224-7.

Raval JA, Patel JK, Li N, Patel MM. Ranitidine hydrochloride floating

matrix tablets based on low density powder: Effects of formulation

and processing parameters on drug release. Asian J Pharm Sci

;2:130- 42.

Khan F, Razzak SM, Khan ZR, Azam KR, Azad MA. Preparation and in vitro evaluation of theophylline loaded gastroretentive floating tablets of

METHOCEL K 4 M. J Pharm Sci 2008;7:65-70.

Deshpande AA, Shah NH, Rhodes CT, Malick W. Development of a

novel controlled release system for gastric retention. Pharm Res

;815-9.

Patel H, Panchal DR, Patel U, Brahmbhatt T. Matrix Type Drug Delivery

System: A Review J Pharm Sci Bioscientific Res 2011;1:143-51.

Sunil K, Jhain, N K, Jhain GP, Agarwal. Gastro retentive floating drug

delivery; An overview: Drug delivery technology 2005;5:21-31.

Mathiowitz, Edith, Ed; Encyclopedia of controlled drug delivery. New

York: John Wiley, I; 1999. p. 9-11.

Kathleen Martindale. The complete drug reference. 32 nd ed.

Pharmaceutical Press: 1999 p. 854-5.

Jaimini M, Rana AC, Thanwar YS. Formulation and evaluation of

famotidine floating tablets. Curr Drug Deliv 2007;04:51-5.

Lindberg NO, Pålsson M, Pihl AC, Freeman R, Freeman T, Zetzener H,

et al. Flow ability measurements of pharmaceutical powder mixtures

with poor flow using five different techniques. Drug Dev Ind Pharm

;30:785-91.

Karkhile VG, Karmarkar RR, Sontakke MA, Badgujar SD, Nemade LS.Formulation and evaluation of floating tablets of Furosemide. Int J

Pharm Res Dev 2010;1:1-9.




DOI: http://dx.doi.org/10.22377/ajp.v6i4.41

Refbacks

  • There are currently no refbacks.