Formulation and evaluation of press coated tablets of esomeprazole for colonic delivery
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Abstract
evaluated for preâ€compression parameters like bulk density, tapped density, angle of repose, carrs index, and hausner’s ratio.Press coated tablets were evaluated for hardness, thickness, friability, tensile strength, drug content, and in vitro drug release. In vitro release studies were performed for 24 hours, first 2 hours in 0.1 N HCl, 3 hours in phosphate buffer (pH 6.8), and then for 19 hours in phosphate buffer (pH 7.4). In vitro drug release studies revealed that the tablets coated with pHâ€dependent,enzymeâ€dependent, and timeâ€dependent polymers showed no drug release in 0.1 N HCl, except for tablets coated with Pectin (25% and 50%, w/w). Kinetic modeling showed that the release exponent (n) value for all formulations was >0.89,indicating super case II transport to be the drug release mechanism. Press coated tablets for colonic delivery of esomeprazole
magnesium trihydrate were successfully developed.
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References
Philip AK, Dabas S, Pathak K. Optimized prodrug approach: A means
for achieving enhanced antiâ€inflammatory potential in experimentally
induced colitis. J Drug Target 2009;17:235â€41.
Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted
drug delivery systems. J Pharm Sci 2003;6:33â€66.
Watts PJ, Illum L. Colonic drug delivery. Drug Dev Ind Pharm
;23:893â€13.
Kinget R, Kalala W, Vervoort L, van den Mooter G. Colonic drug
targeting. J Drug Target 1998;6:129â€49.
Sinha VR, Kumria R. Polysaccharides in colon specific drug delivery:
A review. Int J Pharm 2001;224:19â€38.
Sirkiä T, Salonen H, Veski P, Jürjenson H, Marvola M. Biopharmaceutical
evaluation of new prolongedâ€release pressâ€coated ibuprofen tablets
containing sodium alginate to adjust drug release. Int J Pharm
;107:179â€87.
Ozeki Y, Ando M, Watanabe Y, Danjo K. Evaluation of novel oneâ€step
dry coated tablets as a platform for delayed release tablets. J Control
Release 2004;1:51â€60.
Johnson DA. Review of esomeprazole in the treatment of acid disorders.
Expert Opin Pharmacotherapy 2003;4:253â€64.
Brunton LL, Lazo JS, Parker KL. Goodman and Gilman’s The
Pharmacological Basis of Therapeutics. New York: McGraw Hill; 2006.
Higuchi T. Mechanism of sustainedâ€action medication. Theoretical
analysis of rate of release of solid drugs dispersed in solid matrices.
J Pharm Sci 1963;52:1145â€9.
Hixson AW, Crowell JH. Dependence of reaction velocity upon
surface and agitation (I) theoretical consideration. Ind Eng Chem
;23:923â€31.
Korsmeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. Mechanism
of solute release from porous hydrophilic polymers. Int J Pharm
;15:25â€35.
Soad AY, Ahmed HE, Ibrahim S, Ahmed HS. Optimization of
budesonide compressionâ€coated tablets for colonic delivery. AAPS
Pharm Sci Tech 2009;10:147â€57.
Ashford M, Fell J, Attwood D. Studies on pectin formulations for
colonic drug delivery. J Control Rel 1994;30:225â€32.
Turkoglu M, Ugurlu T. In vitro evaluation of pectinâ€HPMC compression
coated 5â€aminosalicylic acid tablets for colonic delivery. Eur J Pharm
Biopharm 2002;53:65â€73.