Stability study of oral strip for anti-allergic film olopatadine hydrochloride

Abstract

Objective: The aim of the present work was to develop and evaluate the fast-dissolving oral films (FDF) of
olopatadine hydrochloride which is used for the treatment of anti-allergic. This study was to perform evaluation
study of film stability, their stability of oral strip in different temperature for the easy to transport in different areas
that they are not damage for the temperature conditions. Materials and Methods: The olopatadine hydrochloride
film was prepared by solvent-casting method which is used for prepared oral strip such as hydroxypropyl
methylcellulose (HPMC), maltodextrin, and polyethylene glycol, as plasticizers different polymers are used.
Results: The prepared oral strip showed satisfactory results for the evaluation parameters oral strip as optimized
batch was evaluated for stability of film in different temperatures that are used as an in vitro test for the evaluation
of film for storage in different temperatures and their transportation stability. Olopatadine hydrochloride FDF was
developed and evaluated for weight uniformity in vitro dispersion time, in vitro dissolution time, drug content,
and film thickness that the results obtained were within the specified limits. Temperature stability test is used
for high temperature evaluated in hot air oven, and low temperature evaluated in refrigerator. Conclusion: The
FDF prepared with HPMC E-15, at 2, 4, 6, and 8 ratio released the drug up to 98.7% within 2 s which evaluated
that their stability study in different temperatures which are evaluated showed that their stability studies were
conducted for pure drug, polymers, and optimized formulation f6 which indicated that found between the drug
and polymers used in the present studies evaluated that the film is stable in different temperature, polymers, and
optimized formulation F6 which showed that they were no surface fractures and cracks in the films.