Formulation and evaluation of controlled release floating matrix tablets of Stavudine

Suryadevara Vidyadhara, Irukulapati Nagendran, Reddyvalam Lankapalli C. Sasidhar, Vallabhaneni Akhila Devi, Kadiyala Swapna

Abstract


The purpose of this research was to prepare and evaluate floating drug delivery systems of Stavudine. Floating matrix tablets of Stavudine were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The matrix tablets were prepared by direct compression technique, using polymers such as hydroxylpropylmethyl cellulose (HPMC K15M), karaya gum and other standard excipients. Sodium bicarbonate was
incorporated as a gas‐generating agent.The effect of different concentrations of polymers on drug release profile and floating properties were investigated. Comparable release profiles between the commercial product and the designed system were obtained. The matrix formulations were evaluated for physical parameters, drug release by in vitro dissolution studies and in vitro buoyancy studies. Surface characteristics, drug‐excipient interactions and crystal morphology of optimized formulations were evaluated by SEM analysis and DSC studies.


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DOI: http://dx.doi.org/10.22377/ajp.v6i4.44

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