Formulation development and evaluation of orally disintegrating tablets of doxazosin mesylate
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Abstract
of Doxazosin mesylate and to formulate orally disintegrating tablets of taste masked drug. Taste masking was performed by coating Doxazosin Mesylate with suitable polymer Eudragit powdered E-100 using spray drying technique. The resultant microspheres were then evaluated for thermal analysis, yield, particle size, entrapment efficiency and in vitro taste masking.The tablets were formulated by mixing the taste masked microspheres with different types and concentration of superâ€disintegrants and granulated Mannitol was selected as diluent and compressed using direct compression method. The tablets prepared
were evaluated for weight variation, thickness, hardness, friability, drug content, water content, in vitro disintegration time and in vitro drug release and compared with marketed IR tablet of Doxazosin mesylate.
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