Development of Controlled-Release Formulation to Improve Bioavailability of Esomeprazole

Main Article Content

C. Soujanya

Abstract

Aim: The aim of this study was to release the active drug immediately after oral administration, to acquire
quick, and enter systemic drug absorption. Such immediate-release products result in comparatively rapid
drug absorption and onset of associated pharmacodynamic effects. Materials and Methods: The prepared
esomeprazole CR tablets were evaluated for the dissolution studies in acid buffer (pH-1.2) for 2 h, 4.5 pH
acetate buffers for 2 h, 6.8 pH phosphate buffers for 8 h, and 7.4 pH phosphate buffers for 12 h % drug
release that was calculated at various time intervals. Results and Discussion: The present study was aimed
to developing controlled-release tablets of esomeprazole using various polymers. All the formulations were
evaluated for physicochemical properties and in vitro drug release studies. Conclusion: The current research
work envisaged was an attempt to development of controlled-release formulations of esomeprazole to improve
bioavailability.

Downloads

Download data is not yet available.

Article Details

How to Cite
Soujanya, C. . (2022). Development of Controlled-Release Formulation to Improve Bioavailability of Esomeprazole. Asian Journal of Pharmaceutics (AJP), 16(4). https://doi.org/10.22377/ajp.v16i4.4602
Section
ORIGINAL ARTICLES