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Introduction: A wound is categorized as a breakdown or opening of the skin, which could lead to
malfunctioning of the skin. Materials and Methods: Interleukin-1 receptor-associated kinases are key
components in the signal transduction pathways utilized by interleukin-1 receptor and interleukin-18 receptor.
Results and Discussion: The critical role of IRAK-4 in inflammatory processes, and modulation of IRAK-4
kinase activity presents an attractive therapeutic approach for the treatment of inflammatory diseases. To identify
the potent IRAK-4 inhibitors with new anti-inflammatory therapeutic agents from selected herbal plants and
their extract with the help of in-silico data. Conclusion: In the present study, we have investigated in silico
computational studies for Tridax procumbens phytoconstituents against the molecular targets involved in the
anti-inflammatory process. The molecular docking interactions show good binding affinity against the molecular
targets of the anti-inflammatory target, namely, ILAK4. Among the ligands docked against ILAK4, Nodakenin
(14), and Apigenin 7-O-β-D-glucoside (16) showed excellent free energy binding with dock score values of −9.4
and −10 kcal/mol, respectively. These results suggest that further mechanistic studies are to be done for these
phytoconstituents against anti-inflammation.
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