Formulation and optimization of SNEDDS of gliclazide using response surface methodology

Vikrant P Wankhade, Sandeep C Atram, Nishan N Bobade, Srikant D Pande, Kiran K Tapar

Abstract


The aim of the current study was to design an self‐nanoemulsified drug delivery system (SNEDDS) of gliclazide by optimizing the particle size using response surface methodology. SNEDDS were prepared using oils, surfactant and
co‐surfactant. A D‐optimal design for 3 factors at 3‐level each was employed systematically optimize particle size.The particle size was taken as dependent variable. Oil such as Capryol 90, surfactant as Cremophor EL, co‐surfactant as Akoline MCM were taken as independent variables. The counter plot and 3D plot were drawn and optimum formulation were selected by feasibility and grid searches. The polynomial mathematical model generated for response were found to beY = + 148.0778 + 8.1388*A − 0.2556*B − 0.2833*C − 0.2083*A*B − 0.25*A*C +0.0083*B*C +10.35A2 + 2.2 B2 + 2.95C2 and that found to be significant (P < 0.05). Validation of optimization study performed using confirmatory runs, indicated very high degree of prognostic ability of response surface methodology with mean percent error (± S.D.) 5.11.


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References


Shaji J, Lodha S. Response surface methodology for the optimization

of celecoxib self microemulsifying drug delivery system. Indian J Pharm

Sci 2008;70:585‐90.

Wankhade VP, Tapar KK, Pande SD, Bobade NN. Design and evaluation

of self‐nanoemulsifying drug delivery systems for gliglazide, scholar

research library. Der Pharmacia Lettre 2010;2:132‐43.

Deshmukh A, Nakhat P, Yeole PG. Formulation and evaluation of self

emulsifying drug delivery system for fursemide, scholar research library.

Der Pharmacia Lettre 2010;2:94‐106.

Nazzal S, Khan MA. Response surface methodology for optimization

of ubiquinone self‐nanoemulsified drug delivery system. AAPS Pharm

Sci Tech 2002;3:E3.

Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self‐nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of

emulsion formation. Int J Pharm 2002;235:247‐65.

Holm R, Jensen IH, Sonnergaard J. Optimization of self‐microemulsifying

drug delivery systems using a D‐optimal design and the desirability

function. Drug Dev Ind Pharm 2006;32:1025‐32.

Bodea A, Leucuta SE. Optimization of hydrophilic matrix tablets using

a D‐optimal design. Int J Pharm 1997;153:247‐55.

Finsher JH. Particle size of drugs and its relationship to absorption and

activity. J Pharm Sci 1968;57:1825‐35.

Shivkumar HN, Patel PB, Desai BG, Ashok P, Arulmozhi S. Design and

statistical optimization of gliclazide loaded liposphere using response

surface methodology. Acta Pharm 2007;57:269‐85.




DOI: http://dx.doi.org/10.22377/ajp.v6i4.48

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