Formulation and evaluation of meclizine hydro chloride mouth dissolving tablets: An attempt to enhance patent compliance

Article Sidebar

PDF
Published: Aug 26, 2014
DOI: https://doi.org/10.22377/ajp.v6i4.50

Main Article Content

Nimisha Nimisha
Pushplata Pal
Dipti Srivastava

Abstract

The purpose of this research work was to develop mouth dissolving tablets of Meclizine HCL by superdisintegrant addition and sublimation method. Meclizine HCl is an antiâ€emetic drug used for management of dyspepsia, heartburn, epigastric pain,nausea, and vomiting. Sodium starch glycolate was used as super disintregrant and camphor used for enhancement of porosity of the tablets Disintegration time of tablets prepared by superdisintegrant addition were significantly less (P < 0.05) than prepared by sublimation technique hence it was selected for further study. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, disintegration time.All tablet batches passesss evaluation parameters.The physical properties of the prepared tablets did not show any significant variations (P > 0.05) and were found to have good physical integrity. Stability studies showed that the physical and chemical properties of the tested tablets were not altered significantly and all the test formulations were found to be stable.The dissolution profile of fresh and aged Meclizine HCl. MDT showed no significant effect on drug release (P > 0.05).

Downloads

Download data is not yet available.

Article Details

How to Cite
Nimisha, N., Pal, P., & Srivastava, D. (2014). Formulation and evaluation of meclizine hydro chloride mouth dissolving tablets: An attempt to enhance patent compliance. Asian Journal of Pharmaceutics (AJP), 6(4). https://doi.org/10.22377/ajp.v6i4.50
Issue
Vol. 6 No. 4 (2012): Oct-Dec
Section
Articles

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

References

Khattab IS, Zaghloul1 AA, Afouna MI. Studies on the development of

rapidly disintegrating hyoscine butylbromide tablets. Drug Discov Ther

;1:61â€4.

Goel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N, et al. Formulation

design and optimization of mouth dissolving tablets of nimesulide

using vaccum drying technique. AAPS Pharma Sci Tech 2004;5:36.

Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation

and evaluation rapidly disintegrating fenoverine tablets: Effect of

superdisintegrants. Drug Dev Ind Pharm 2007;33:1225â€32.

Charman WN. Lipids, lipophilic drugs, and oral drug deliveryâ€some

emerging concepts. J Pharm Sci 2000;89:967â€78.

Hardman JB, Limbird LE, Gilman AG. Goodman and Gilman’s, The

Pharmcological basis of therapeutics, 10th ed. McGrawâ€Hill Companies

Inc; 1996. p. 749.

Pulsipher MA, Young NS, Tolar J, Risitano AM, Deeg HJ, Anderlini P,

et al. Optimization of therapy for severe aplastic anemia based on

clinical, biologic, and treatment response parameters: Conclusions of

an international working group on severe aplastic anemia convened by

the blood and marrow transplant clinical trials network, March 2010.

Biol Blood Marrow Transplant 2011;17:291â€9.

Ahmed IS, Fatahalla FA. Pilot study of relative bioavailability of two

oral formulations of ketoprofen in healthy subjects, a fast dissolving

lyophilized tablet as compared to immediate release tablet. Drug Dev

Ind Pharm 2007;33:505â€11.

Shrisand SB, Suresh S, Swamy PV, Para MS, Nagendra KD. Formulation

design of fast disintegrating tablet using disintegrant blends. Ind J

Pharm Sci 2010;72:130â€1.

Bhardwaj V, Sharma PK. Formulation and evaluation of fast dissolving

tablets of amlodipine besylate using different super disintegrants and

camphor as sublimating agent. Amâ€Eur J Sci Res 2010;5:264â€69.

Li MJ, Li AQ, Xia H, Zhao CZ, Li CS, Wan SB, et al. Cloning and sequence analysis of putative type II fatty acid synthase genes from arachis hypogaea L. J Biosci 2009;34:227â€38.

Sawarikar PP. Formulation and evaluation of fast dissolving/disintegrating tablets of isoxsuprine hydrochloride. J Curr Pharma Res 2010;3:41â€46.

Shukla D. Mouth dissolving tablets II: An overview of evaluation

techniques. Sci Pharm 2009;77:327â€41.

Singh SK. Fast disintegrating combination tablets of omeprazole and

domperidone. Asian J Pharma Clin Res 2009;2:54â€62.

Rizwanulla R. Preparation and evaluation of oxcarbazepine fast

dissolving tablets. Int J Pharma Professional’s Res 2011;2:99â€101.

Gudas GK. Formulation and evaluation of fast dissolving tablets of

Chlorpromazine HCL. J Pharm Sci Technol 2010;2:99â€102.

Ishikawa T, Watanabe Y, Utoguchi N, Matsumoto M. Preparation

and evaluation of tablets rapidly disintegrating in saliva containing

bitterâ€tasteâ€masked granules by the compression method. Chem Pharm

Bull 1999;47:1451â€4.

Goel H, Rai P, Rana V, Tiwary AK. Orally Disintegrating Systems:

Innovations in Formulation and Technology. Recent Pat Drug Deliv

Formul 2008;2:258â€74.