Across-Sectional Observational Study on Drug Utilization and Prescribing Patterns of Antibiotics in Lower Respiratory Tract Infections in Tertiary Care Teaching Hospital
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Abstract
Background: Lower respiratory tract infections (LRTIs) affect the airways and lungs, including conditions such as
bronchitis, bronchiolitis, and pneumonia. These infections are a leading cause of mortality from infectious diseases
worldwide, often caused by bacterial and viral pathogens. Despite their prevalence, antibiotic prescribing trends in
LRTIs remain underexplored, particularly in Indian healthcare settings. Objectives: This study investigates the patterns
of antibiotic prescription for LRTIs, including bronchitis, in a tertiary care teaching hospital, with a focus on monoand
poly-antibiotic therapies. Methods: A cross-sectional observational study was conducted at Sri Venkateswara
Institute of Medical Science, Tirupathi, India. Data were collected from 72 participants, including demographic
information, clinical history, and self-medication practices. Statistical analysis was performed using the Statistical
Package for Social Sciences software. The study focused on prescription patterns, gender distribution, and the types
of antibiotics prescribed. Results: A greater proportion of males than females were found to suffer from LRTIs. Out
of the total prescriptions analyzed, 57% were for mono-antibiotic therapy, while 7% involved poly-antibiotic therapy.
LRTI diagnoses, including non-specific LRTI, pneumonia, tuberculosis, and pleural effusion, accounted for 76.28% of
the cases, with 23.6% of the cases attributed to bronchitis. Augmentin and doxycycline were the two most frequently
prescribed antibiotics. A comparison of the prescribed daily dose and defined daily dose of antibiotics was performed.
Conclusions: The study highlights the predominant use of mono-antibiotic therapy over poly-antibiotic therapy in
treating LRTIs. The findings underscore the need for better antibiotic stewardship to manage the rising number of
LRTI patients. Further efforts are required to optimize treatment strategies and reduce the risk of antibiotic resistance.
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