Synthesize and Characterize the Lipoid S-75 Conjugated Chitosan-Based Micelles for Improving Biopharmaceutical Parameters of Resveratrol

Abstract

The anticancer activity of resveratrol is well known. But because of its limited water solubility and low
bioavailability, resveratrol (RES) is a BCS class II medication with research potential. The current work creates
a new copolymer from Lipoid S-75 and chitosan and tests the RES-loaded micelles it produces for varied
delivery properties. In addition to efficiently loading the drug, the nanometric micellar carriers also regulated
the rate of RES release. The discoveries using a novel polymer-based carrier show promise for improved
medication delivery in the future. Aim: The aim of the study was to synthesize and characterize the lipoid S-75
conjugated chitosan-based micelles for improving biopharmaceutical parameters of resveratrol. Methods: The
preparation and characterization of a copolymer of CS and lipoid S-75 were done by using S-75 100 mg and
DCC 700 mg which is followed by preparation and characterization of CS-lipoid S-75-conjugated resveratrol
micelles. And evaluation of the formulation done by the parameters such as particle size, polydispersity
index zeta potential, % encapsulation efficiency and drug loading, drug loading capacity, and differential
scanning calorimetry. Results: In the present study, development of polymeric micelles using the flavonoid
in multifaceted applications, entailing therapy, diagnostics, in-suit imaging, and on-demand drug delivery,
resveratrol, polymers such as chitosan, and lipoid S-75 show significant potential. The fundamental formation
mechanisms are then analyzed, focusing on the inherent physicochemical qualities like solubility and
bioavailability that control the drug release. Conclusion: The development of resveratrol-loaded chitosanbased
S-75 micelles demonstrates considerable potential for multifaceted biomedical applications, including
therapy, diagnostics, in-situ imaging, and on-demand drug delivery. The combination of resveratrol, chitosan,
and lipoid S-75 results in a polymeric micellar system with enhanced solubility and bioavailability, addressing
the challenges associated with the poor aqueous solubility and rapid metabolism of resveratrol. The analysis
of the micelle formation mechanisms highlights the crucial role of the inherent physicochemical properties
in controlling drug release. This innovative micellar platform offers promising avenues for optimizing the
therapeutic delivery of resveratrol and broadening its application scope in pharmaceutical and biomedical
fields.