Formulation and Evaluation of Wrightia tinctoria Emulgel for the Treatment of Psoriasis

Abstract

Aim: Psoriasis can be a debilitating condition, but there may be a solution. Recently, several studied showed
that emulsion-based topical drug delivery system could be a promising approach for the treatment of psoriasis.
Hence, in the present study, Wrightia tinctoria (WT) oil-based emulgel was developed for the enhancement of
effectiveness against psoriasis. Materials and Methods: This breakthrough treatment could be an alternative
technique for the management of psoriasis. WT oil was used to prepare emulsions, which was loaded into a gel
base. The concentration different excipients varied to prepare various emulsion formulations and evaluated for
different parameters. The developed formulations were evaluated for the various parameters such as drug content,
particle size, zeta potential, viscosity, pH and percentage drug release. Results and Discussion: The optimized
formulation (F4) was found to have droplet size of 3218 ± 1.24 nm, 0.0175 ± 1.78 V zeta potential, entrapment
efficiency of 59.53 ± 8.42%, and spreadability of 2.901 ± 0.12 mm. The pH and viscosity of optimized WT oil-based
emulgel was found to be 6.1 ± 0.578 and 94,374 ± 198 cp, respectively. In vitro release of WT oil from optimized
emulgel was found to be 98.87 ± 1.15% in 10 h. In 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide
cytotoxicity study indicated no significant difference between the WT oil and its emulgel. Thus, suggested no
loss of anti-proliferation activity of WT oil on formulation in emulgel. Conclusion: This study showed that the
emulgel formulation has the potential to significantly enhance the efficacy of WT oil in treating psoriasis. These
findings provide exciting new possibilities for improving psoriasis treatment and highlight the importance of
continued research in this area.