Novel eatable silk fibroin gels containing salbutamol sulphate for dysphagic and geriatric patients
Main Article Content
Abstract
natural polymer silk fibroin of different concentrations was subjected for in vitro characterization.The effect of concentration of the solution on gelation time, viscosity, and drug release was studied. FTIR and DSC spectra reveal that the drug was found compatible with silk fibroin. TGA curves showed weight loss as the temperature increased. Formulations F3, F4, F6, and F9 had thin, nectar like, honey like, and spoon thick viscosity range respectively, which is considered suitable for dysphagia patients as given by National Dysphagia Diet Task Force. Formulations showed shear thinning pseudoplastic behavior. Based on the concentration and viscosity of the polymer, formulation F9 was found to sustain the release of drug up to 90 min (99.4 ± 0.5%), whereas F3 showed release within 5 min (99.2 ± 2.0%). Mechanism of drug release was found to be anomalous transport. All formulations were found stable after 6 months when kept at refrigerated temperature (4°C – 8°C) and room temperature. It can be concluded that the salbutamol sulphate gels prepared are suitable as vehicles
for dysphagic patients.
Downloads
Article Details
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
References
Dixit AS, Parthasarathi KK, Hosakote GS. Gels and Jellies as a Dosage
Form for Dysphagia Patients: A Review. Curr Drug Ther 2011;6:79-6.
Jackson LD, Little J, Kung E, William EM, Siemiatkowska K, Plowman S.
Safe medication swallowing in Dysphagia: A collaborative improvement
project. Healthc Q 2008;11:110-6.
Guidance for Medication Assessment in Patients with Swallowing
(Dysphagia) or Feeding Disorders Pharmacy Benefits Management-
Strategic Healthcare Group (PBM). Available from: http://www.
pbm.va.gov/Clinical%20Guidance/Clinical%20Recommendations/
Dysphagia,%20Recommendations%20for%20Medication%20Assessment.
pdf http://www.pbm.va.gov/Clinical%20Guidance/Clinical%20
Recommendations/Dysphagi,%20Recommendations%20for%20
Medication%20Assessment.pdf. [Last accessed on 2010 Jul 14].
CPLOL – Prevention Commission Dysphagia Review 2004-2005.
Available from: www.cplol.eu/files/CPLOL_dysphagiareport_en.pdf.
[Last accessed on 2010 Jul 14].
Domenico LU. Asthma in the Elderly. Curr Gerontol Geriatr Res
;2009:1-5.
Bisch EM, Logemann JA, Rademaker AW, Kahrilas PJ, Lazarus CL.
Pharyngeal effects of bolus volume, viscosity, and temperature in
patients with dysphagia resulting from neurologic impairment and in
normal subjects. J Speech Hear Res 1994;37:1041-59.
Dantas RO, Kern MK, Massey BT, Dodds WJ, Kahrilas PJ, Brasseur JG,
et al. Effect of swallowed bolus variables on oral and pharyngeal phases
of swallowing. Am J Physiol 1990;258:G675-81.
Videofluoroscopy swallow study. Available from: http://www.dukehealth.
org/cancer/health_library/care_guides/treatment_instructions/
videofluoroscopicswallowstudy. [Last accessed on 2011 Dec 5].
Videofluoroscopy Swallowing study. Available from: http://www.asha.
org/public/speech/swallowing/VFSS.htm. [Last accessed on 2011 Jul 25].
Thickened liquids consistency for safer swallowing. Available from:
https://patienteducation.osumc.edu/Documents/thickened-liquids.pdf
http://patienteducation.osumc.edu/Documents/thickened-liquids.pdf.
[Last accessed on 2011 Jul 25].
The National Dysphagia Diet Task Force. The National Dysphagia
Diet: Standardization for optimal care. Chicago: American Dietetic
Association; 2002.
Morita T. Development of deglutition aid jelly for oral administration.
Yakugaku Zasshi 2003;123:665-1.
Nogueira GM, Rodas AC, Leite CA, Giles C, Higa OZ, Polakiewicz B, et al.
Preparation and characterization of ethanol-treated silk fibroin dense
membranes for biomaterials application using waste silk fibers as raw
material. Bioresour Technol 2010;101:8446-51.
Grinia MN, Raquel FW, Wellington CV, Bronislaw P, Andrea CDR, Olga ZH,
et al. A New Method to Prepare Porous Silk Fibroin Membranes Suitable
for Tissue Scaffolding Applications. J Appl Polym Sci 2009;114:617-3.
Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. New
oral dosage form for elderly patients: Preparation and characterization
of silk fibroin gel. Chem Pharm Bull (Tokyo) 1995;43:284-8.
Gohel MC, Parikh RK, Nagori SA, Shah SN, Dabhi MR. Preparation and
evaluation of soft gellan gum gel containing paracetamol. Indian J
Pharm Sci 2009;71:120-4.
Dhawan S, Medhi B, Chopra S. Formulation and evaluation of diltiazem
hydrochloride gels for the Treatment of anal fissure. Sci Pharm
;77:465-2.
Mohapatra A, Parikh RK, Gohel MC. Formulation, development and
evaluation of patient friendly dosage forms of metformin, Part-II: Oral
soft gel. Asian J Pharm 2008;2:172-6.
Dabhi M, Gohel M, Parikh R, Sheth N, Nagori S. Formulation
development of ambroxol hydrochloride soft gel with application of
statistical experimental design and response surface methodology. PDA
J Pharm Sci Technol 2011;65:20-31.
Gerentes P, Vachoud L, Doury J, Domard A. Study of a chitin-based
gel as injectable material in periodontal surgery. Biomaterials
;23:1295- 302.
Nouh AT, Abd El-Gawad AH, Guda TK. Formulation and bioavailability of
controlled release Salbutamol sulphate tablets using natural additives.
Drug Discov Ther 2010;4:85-92.
Strowd L, Kyzima J, Pillsbury D, Valley T, Rubin B. Dietary guidelines
and the rheology of nutritional feeds and barium test feeds. Chest
;133:1397-1.
Garcia JM, Chamber E 4 th . Managing dysphagia through diet
modifications. Am J Nurs 2010;110:26-33; quiz 34-5.
Ayub ZH, Hirabayashi K, Arai M. Effect of pH on silk fibroin gelation.
Sen-I Gakkaishi 1992;48:141-4.
Freddi G, Pessina G, Tsukada M. Swelling and dissolution of silk fibroin
(Bombyxmori) in N-methyl morpholine N-oxide. Int J Biol Macromol
;24:251-63.
Abd El-Halim SM, Amin MM, El-Gazayerly ON, Abd El-Gawad NA.
Comparative study on the different techniques for the preparation of
sustained-release hydrophobic matrices of a highly water-soluble drug.
Drug Discov Ther 2010;4:484-2.
Germain I, Dufresne T, Ramaswamy HS. Rheological characterization
of thickened beverages used in the treatment of dysphagia. J Food Eng
;73:64-74.
Steele CM, van Lieshout PH, Goff HD. The rheology of liquids: a
comparison of clinicians’ subjective impressions and objective
measurement. Dysphagia 2003;18:182-95.
Dixit AS, Charyulu N, Nayari H. Design and evaluation of novel emulgel
containing acyclovir for herpes simplex keratitis. Lat Am J Pharm
;30:844-2.