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sodium alginate (SA) and another plant seed mucilage dillenia (obtained from Dillenia indica, Family, Dilleniaceae) using orificegelation technique and systematically evaluating in vitro by using scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffractometer (XRD). The microcapsules were smooth and elegant in appearance showed no visible cracks as confirmed by SEM; and extended drug release of 72.682% upto 12 hours in phosphate buffer of pH 6.8; showing particle size within the range of 371.5-457 Î¼m, and less angle of repose,
Hausnerâ€™s ratio and Carrâ€™s consolidation index; and showed encapsulation efficiency of 63.068 Â± 0.002 to 99.083 Â± 0.017%.Thein vitro release data of optimized batch of microcapsules were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release, which followed zero order kinetics and value of â€œn,â€ is calculated to be 0.505 and drug release was
diffusion controlled.The in vivo antihyperlipidemic activity of formulations in mice was carried out developing hyperlipidemia in mice and then administering the optimized formulations orally, and the formulation showed promising results.
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