Formulation and in -vitro evaluation of chrysophanol topical gel

Deepa T Vasudevan, S Gopalakrishnan, Kavitha R Dinesh, KG Ravikumar, KR Sundaram, AKK Unni

Abstract


This study describes the formulation and characterization of topical gel of chrysophanol containing carbopol as gel base. The partition of drug between skin and the hydrogel matrix was considered to play an important role in the permeation process. The effect of three levels of carbopol and three different permeation enhancers on chrysophanol permeability was determined in vitro. Each formulation was characterized in terms of viscosity, pH, extrudability, spreadability, homogenicity, drug content, skin irritation, stability, and drug release studies. The gel consisting of 1% carbopol as gel base and 15% dimethylsulfoxide showed superior physicochemical and permeability properties and it was ranked best. Reports of
pharmacokinetic parameters showed that the drug release is controlled by both diffusion and relaxation processes.


Full Text:

PDF

References


Deepa TV, Kavitha RD, Gopalakrishnan S, Sreekanth SK, Shekar S. The

Potential of Aqueous and Isolated Fraction from Leaves of Cassia fistula

Linn as Antibacterial Agent. Int J Chem Sci 2009;7:4,2363-2370.

Ratner B, Hoffman A. Synthetic hydrogels for biomedical application.

Hydrogels Medical, Related, Applications. ACS, Symposium Series,

No. 31, In: Andrade JD, ed.Andrade JD.Washington,DC:Am.Chem.

Society1976;1-36.

Peppas N, Bures P, Leobandung W, Ichikawa H. Hydrogels in

pharmaceutical formulation. Eur J Pharm 2000;50:27-46.

Kumar S, Himmelsten K. Modification of in situ gelling behavior of

carbopol solution by Hydroxypropyl methyl cellulose. J Pharm Sci

;84:344-8.

Jones DS, Irwin CR, Woolsen AD, Djok J, Adams V. Physicochemical

Characterization and Preliminary Invivo Efficiency of Bioadhesive

Semisolid Formulations Containing Flubiprofen for Treatment of

Ginjivitis. J Pharm Sci 1999;88:592-8.

Mutimer MN, Riffkin C, Hill JA, Glickman ME, Cyr GN. Modern ointment

base technology. II. Comparative evaluation of bases. J Am Pharm Assoc

Sci 1956;45:212-8.

Liberman HA, Rieger MM, Banker GS. Pharmaceutical Dosage Form,

Disperse Systems. Vol. 3. New York: Marcel Dekker; 1989. p. 594.

Deepa TV, Kavitha RD, Gopalakrishnan S, Ravikumar KG, Sundaram KR,AneeshTP. Development and Validation of Spectrophotometric Method

for Chrysophanol in Gel Formulations. Int J Drug Dev Res 2010;2:2.

Marzulli FN, Maibach HI. Advance in Modern Toxicology. Vol.4. London:

Hemisphere Publishing Corporation; 1997. p. 193-210.

Sperling, F. Toxicology Principles and Practice. Vol. 4. New York:

WileyInterscience Publication; 1984. p. 168-77.

Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P. Electrospun

cellulose acetate fiber mats containing curcumin and release

characteristic of the herbal substance. Polymer 2007;48:7546-57.

Taepaiboon P, Rungsardthong U, Supaphol P. Vitamin-loaded

electrospuncellulose acetate nanofiber mats as transdermal and

dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm

Biopharm 2007;67:387-97.

Siddaramaiah, Kumar P, Divya K, Mhemavathi B, Manjula D. Chitosan/

HPMC Polymer Blends for Developing Transdermal Drug Delivery Systems.

J Macrom Sci Part A- Pure and Applied Chemistry. 2006;43:601-7.

Mei Z, Chen H, Wang T, Yang Y, Yang X. Solid lipid nanoparticle and

microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm

;56:189-96.

Shah KA, Date AA, Joshi MD, Patravale VB. Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery. Int J Pharm 2007;345:163-71.

Komatsu H, Suzuki M. Percutaneous absorption of butylparaben

through guinea pig skin in vitro. J Pharm Sci 1979;68:596-8.

Higuchi WI. Analysis of data on the medicament release from ointments. J Pharm Sci 1962;51:802-4.

Peppas NA. Analysis of Fickian and non-Fickian drug release from

polymers, Pharm. Acta Helv 1985;60:110-11.

Peppas NA, Sahlin JJ. A simple equation for the description of

solute release. III. Coupling of diffusion and relaxation Int J Pharm

;57:169-72.

Hadjiioannou TP, Christian GD, Koupparis MA, Macheras PE.

Quantitative Calculations in Pharmaceutical Practice and Research.

New York: VCH Publishers Inc; 1993. p. 345-8.




DOI: http://dx.doi.org/10.22377/ajp.v5i2.94

Refbacks

  • There are currently no refbacks.