Paclitaxel loaded poly(sebacic acid-co-ricinoleic ester anhydride)-based nanoparticles

Santosh B Totiger, Jagadeesh G Hiremath

Abstract


The main objective of the present study was to prepare paclitaxel (PTX)-loaded poly(sebacic acid-co-ricinoleic ester anhydride) (poly (SA-RA) 70:30 w/w)-based nanoparticles (NPs). PTX- Poly (SA-RA) NPs were prepared by solvent
displacement technique. The prepared formulations were characterized in terms of particle size and distribution, surface morphology using Malvern laser analyzer, scanning electron microscope (SEM). Drug physical and chemical state were
determined by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry. The particles obtained were spherical in shape with a smooth surface and mean particle size in the range of
443-436 nm. The entrapped PTX within the polymer matrix was in the form of amorphous state.


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DOI: http://dx.doi.org/10.22377/ajp.v5i4.111

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